{"id":"W2275112317","doi":"10.1128/jvi.02973-15","title":"Nef Proteins from HIV-1 Elite Controllers Are Inefficient at Preventing Antibody-Dependent Cellular Cytotoxicity","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Biology; Epitope; Downregulation and upregulation; Viral replication; Virology; Antibody; Immune system; Glycoprotein; Cytotoxicity; Tetherin; Virus; Cell biology; Immunology; In vitro; Molecular biology; Monoclonal antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002863079,0.0003190475,0.0002708812,0.0001655331,0.0001371166,0.0003953788,0.0004167977,0.0004217719,0.001118436],"category_scores_gemma":[0.0004381815,0.00007568373,0.000150293,0.0001076307,0.0002083375,0.000227393,0.0002032949,0.0004879971,0.0003024164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885566,"about_ca_system_score_gemma":0.0000770836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002896172,"about_ca_topic_score_gemma":0.0002501386,"domain_scores_codex":[0.9998436,0.00002650944,0.00001545518,0.00002028865,0.00004893968,0.00004506733],"domain_scores_gemma":[0.9997125,0.0001101591,0.00004478663,0.00003815003,0.00003609616,0.00005818632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002240152,0.00009774679,0.0008105458,0.00003378126,0.00001240731,0.0001227269,0.00001943367,0.00007678229,0.9950944,0.00008311469,0.00006904975,0.003355919],"study_design_scores_gemma":[0.0001186847,0.001721383,0.01774349,0.00002112642,0.00006429834,0.002460381,0.00005497878,0.001927771,0.9707541,0.0001056917,0.005016977,0.00001100338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974381,0.0008671066,0.0009666402,0.00003143113,0.00001428858,0.00002124286,0.00009409184,0.00002368589,0.0005433914],"genre_scores_gemma":[0.9959091,0.0004012183,0.001509103,0.0000875587,0.00002158221,0.00002703723,0.0007548928,0.00001813446,0.001271344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001118436,"threshold_uncertainty_score":0.003741503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01970687543196042,"score_gpt":0.2691508746662864,"score_spread":0.249443999234326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}