{"id":"W2275112317","doi":"10.1128/jvi.02973-15","title":"Nef Proteins from HIV-1 Elite Controllers Are Inefficient at Preventing Antibody-Dependent Cellular Cytotoxicity","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Biology; Epitope; Downregulation and upregulation; Viral replication; Virology; Antibody; Immune system; Glycoprotein; Cytotoxicity; Tetherin; Virus; Cell biology; Immunology; In vitro; Molecular biology; Monoclonal antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008118282,0.000212412,0.0006242886,0.0001902857,0.000155433,0.00001706158,0.0003228592,0.0002778117,0.0005263977],"category_scores_gemma":[0.0002957065,0.0001576471,0.0002223889,0.00008252126,0.0002145821,0.00009012248,0.0001968404,0.0005731705,0.001277248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002465985,"about_ca_system_score_gemma":0.0001709705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007760048,"about_ca_topic_score_gemma":0.0000514253,"domain_scores_codex":[0.9977165,0.0006895619,0.0006367892,0.0002551021,0.0001509251,0.0005510484],"domain_scores_gemma":[0.9984884,0.0001705193,0.0006924153,0.0002610945,0.000230137,0.0001574179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002429857,0.0007761511,0.04061696,0.000007396726,0.0008035497,0.0006935302,0.0004453713,0.0002428823,0.9506366,0.0000209225,0.002635008,0.0006917699],"study_design_scores_gemma":[0.05743438,0.007795002,0.1100454,0.0003158558,0.0006727581,0.001863509,0.001480275,0.0001768576,0.7205971,0.0006416755,0.09808994,0.0008872304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888467,0.007413056,0.001173948,0.001046889,0.0005290302,0.0003815396,0.0001499412,0.00001756133,0.0004413509],"genre_scores_gemma":[0.9979023,0.0001405021,0.0001810458,0.0001509671,0.0001462086,0.00001194004,0.0001036889,0.00001723245,0.001346144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2300395,"threshold_uncertainty_score":0.9995004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01970687543196042,"score_gpt":0.2691508746662864,"score_spread":0.249443999234326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}