{"id":"W2275203522","doi":"10.1371/journal.pone.0128109","title":"Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Cancer Institute; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Centre for Addiction and Mental Health Foundation; Abramson Cancer Center; University of Pennsylvania; Pennsylvania Department of Health","keywords":"Varenicline; Smoking cessation; Medicine; Bupropion; Internal medicine; Placebo; Nicotine; Nicotine replacement therapy; Haplotype; Genotype; Genetics; Pathology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002355486,0.0002348835,0.0008278745,0.0003641531,0.0005248612,0.0006292729,0.000358278,0.0005962746,0.002242628],"category_scores_gemma":[0.004224256,0.0001929138,0.001074081,0.000532279,0.0004665411,0.000230472,0.0002564102,0.0005016683,0.0002157481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002878549,"about_ca_system_score_gemma":0.0003635421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007701519,"about_ca_topic_score_gemma":0.009858458,"domain_scores_codex":[0.9977021,0.0009432256,0.0002608467,0.0005806535,0.0003478947,0.0001653279],"domain_scores_gemma":[0.9977235,0.0008751188,0.0006420133,0.0003394183,0.0002098541,0.0002101102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006112642,0.0002268139,0.9537261,0.0001249675,0.00347229,0.0002981225,0.0004835823,0.0001590059,0.01954081,0.0001643847,0.0002784391,0.01541292],"study_design_scores_gemma":[0.0000711114,0.0003958305,0.9972761,0.00001730806,0.0007320331,0.0001603105,0.0001061884,0.0002285621,0.0004069469,0.0001198355,0.0004802805,0.00000547877],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966398,0.001115723,0.0004014005,0.0001500417,0.00002115234,0.00001812328,0.0002300724,0.000007518222,0.001416125],"genre_scores_gemma":[0.9994137,0.0000915971,0.00007950546,0.00007793423,0.0000122786,0.00001185489,0.000128887,0.000003941385,0.000180301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007701519,"threshold_uncertainty_score":0.01531339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1520241421331584,"score_gpt":0.3262910917103227,"score_spread":0.1742669495771643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}