{"id":"W2275529291","doi":"10.69645/gged9050","title":"The blood-brain barrier and CNS drug development","year":2008,"lang":"en","type":"article","venue":"The biomedical & life sciences collection.","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Blood–brain barrier; Drug; Drug development; Neuroscience; Medicine; Pharmacology; Psychology; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":["sts"],"category_scores_codex":[0.001363634,0.0001439835,0.0002151441,0.00008202287,0.004884242,0.00004018352,0.0002251236,0.00005615514,0.0001135719],"category_scores_gemma":[0.0008117309,0.00006258769,0.00005780754,0.001126208,0.003695588,0.0000539664,0.0001746572,0.0002717614,0.00002491801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004290508,"about_ca_system_score_gemma":0.0005970583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004401317,"about_ca_topic_score_gemma":0.00006078737,"domain_scores_codex":[0.9981218,0.0001364928,0.0002746701,0.0003187117,0.0007465195,0.000401803],"domain_scores_gemma":[0.9981505,0.001225839,0.00006309719,0.0001136021,0.00006194028,0.000384998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002212702,0.0006893234,0.01489602,0.00005015045,0.000471485,0.0001316174,0.004928454,0.000005887589,0.005082965,0.0005171704,0.9597225,0.01328316],"study_design_scores_gemma":[0.001731172,0.0006751767,0.075392,0.00003218943,0.00008258125,0.0003423242,0.0007469577,0.001537392,0.0007884526,0.0003076411,0.9181576,0.0002064989],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9237036,0.002594608,0.0001938684,0.06563167,0.000875132,0.0007009538,0.000002910541,0.0001102413,0.006187021],"genre_scores_gemma":[0.9714489,0.0005910263,0.0003457656,0.008485856,0.0003510847,0.00009245757,0.000001046006,0.000006118918,0.01867777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06049598,"threshold_uncertainty_score":0.9990158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02702866943489891,"score_gpt":0.2938192666513176,"score_spread":0.2667905972164187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}