{"id":"W2275578334","doi":"10.1016/j.actbio.2016.01.025","title":"Small hydrophobe substitution on polyethylenimine for plasmid DNA delivery: Optimal substitution is critical for effective delivery","year":2016,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Thailand Research Fund; Canadian Cancer Society","keywords":"Polyethylenimine; Transfection; Gene delivery; Chemistry; Biophysics; Hydrophobe; Cationic polymerization; Polymer; Polymer chemistry; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002561939,0.0002733253,0.0002047645,0.00009004919,0.0001507122,0.0001979491,0.0001449338,0.000302255,0.0009182798],"category_scores_gemma":[0.0004572246,0.0001487912,0.0001197453,0.0001204485,0.0003264514,0.0003742543,0.0001945028,0.0004065432,0.0002873572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002435255,"about_ca_system_score_gemma":0.0002764951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002884087,"about_ca_topic_score_gemma":0.0006905211,"domain_scores_codex":[0.9998572,0.00002907142,0.00001581322,0.00002505129,0.00004264824,0.00003019129],"domain_scores_gemma":[0.9997857,0.00007856228,0.0000601833,0.00002499614,0.00002562324,0.00002494953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000372281,0.000005195669,0.00005076505,0.00002939457,0.000001912598,0.00002897113,0.0000121281,0.00005252738,0.9987054,0.000104891,0.00002042677,0.0009510714],"study_design_scores_gemma":[0.00000398045,0.0000456113,0.0003175977,0.00000254656,0.000004272232,0.00004816113,0.000007120526,0.000302492,0.9985084,0.00002569507,0.0007307775,0.000003394003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826939,0.001039469,0.0141154,0.0002656202,0.00003866884,0.00007377351,0.00008880218,0.0001219621,0.001562428],"genre_scores_gemma":[0.9919165,0.0006515826,0.006194427,0.00005735971,0.000009655233,0.00003916053,0.00009277085,0.00003608683,0.001002363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009182798,"threshold_uncertainty_score":0.003071904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122257972945541,"score_gpt":0.2675892978488598,"score_spread":0.2463667181194044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}