{"id":"W2275578334","doi":"10.1016/j.actbio.2016.01.025","title":"Small hydrophobe substitution on polyethylenimine for plasmid DNA delivery: Optimal substitution is critical for effective delivery","year":2016,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Thailand Research Fund; Canadian Cancer Society","keywords":"Polyethylenimine; Transfection; Gene delivery; Chemistry; Biophysics; Hydrophobe; Cationic polymerization; Polymer; Polymer chemistry; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000184428,0.000319506,0.0002569129,0.0000905892,0.0001914901,0.00006610345,0.0002489587,0.0003549819,0.00004482088],"category_scores_gemma":[0.0002095285,0.0002460767,0.0002216885,0.00005305024,0.0002136488,0.00002370247,0.00007722441,0.00002857736,0.00004868712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007081978,"about_ca_system_score_gemma":0.00007921043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002934753,"about_ca_topic_score_gemma":0.000009645794,"domain_scores_codex":[0.9983752,0.0000578246,0.0003067585,0.0006656926,0.0001160522,0.0004785181],"domain_scores_gemma":[0.9990667,0.00009446865,0.0000965859,0.0003598398,0.0002611899,0.0001212793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00385518,0.0001138708,0.00006806573,0.00005865246,0.00009893278,0.00000332746,0.00002465902,0.000002350342,0.9883798,0.0003937739,0.005709919,0.001291458],"study_design_scores_gemma":[0.001814854,0.002373715,0.000553096,0.0001100961,0.00008107728,0.0000130497,0.00001464757,0.00008179848,0.9669218,0.0001015566,0.0275578,0.0003765286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862782,0.0001248004,0.009462284,0.0005550614,0.001700292,0.000814868,0.0009926591,0.00003959107,0.0000322857],"genre_scores_gemma":[0.9968189,0.00009066647,0.0008555694,0.0004462352,0.0007949364,0.0003683775,0.000373322,0.00003768695,0.0002142898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02184788,"threshold_uncertainty_score":0.9999992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122257972945541,"score_gpt":0.2675892978488598,"score_spread":0.2463667181194044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}