{"id":"W2275709532","doi":"10.1093/jncimonographs/lgv015","title":"RNA Disruption and Drug Response in Breast Cancer Primary Systemic Therapy","year":2015,"lang":"en","type":"article","venue":"JNCI Monographs","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University; Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Systemic therapy; Breast cancer; Oncology; Drug; Cancer; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001163638,0.0002143581,0.0004080102,0.0004657659,0.0001617007,0.00035158,0.0001750859,0.0003001739,0.001455003],"category_scores_gemma":[0.001524809,0.0001040685,0.0002027821,0.0003577849,0.000294621,0.0001860048,0.0002661971,0.000584468,0.0003964837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005138475,"about_ca_system_score_gemma":0.0001905728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000435945,"about_ca_topic_score_gemma":0.0007375045,"domain_scores_codex":[0.9993753,0.0002004271,0.00004774998,0.0001208331,0.0002085011,0.00004717392],"domain_scores_gemma":[0.9985763,0.0003557152,0.0007353358,0.00008390125,0.0001284302,0.0001203346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02748709,0.001357326,0.4729662,0.0007080551,0.0005264037,0.0001832076,0.0003139914,0.003571263,0.3234823,0.0001859407,0.001781183,0.167437],"study_design_scores_gemma":[0.0002289595,0.01550733,0.9186598,0.0000390041,0.0001903656,0.0007111717,0.00007579871,0.002393287,0.05865345,0.0001753203,0.003342913,0.0000226306],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988262,0.006832497,0.002061213,0.0001383223,0.00002293781,0.0001379802,0.0007579185,0.00008486565,0.001702197],"genre_scores_gemma":[0.9969286,0.0005271378,0.001192594,0.0000975065,0.0000145927,0.0001007065,0.0005405229,0.000009105413,0.0005892161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455003,"threshold_uncertainty_score":0.006153941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163152112404763,"score_gpt":0.2765481739785503,"score_spread":0.2649166528545027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}