{"id":"W2275789744","doi":"10.1128/aac.02278-15","title":"HIV-1 Alters Intestinal Expression of Drug Transporters and Metabolic Enzymes: Implications for Antiretroviral Drug Disposition","year":2016,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Abcg2; Multidrug resistance-associated protein 2; CYP3A4; Biology; Drug metabolism; Drug resistance; Efflux; Pharmacology; P-glycoprotein; Multiple drug resistance; Efavirenz; Drug; ATP-binding cassette transporter; Transporter; Cytochrome P450; Immunology; Viral load; Enzyme; Human immunodeficiency virus (HIV); Microbiology; Gene; Biochemistry; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001064991,0.0001674047,0.0002123785,0.0001306869,0.0001351516,0.0004147454,0.00007483787,0.0002497261,0.001235481],"category_scores_gemma":[0.0001773228,0.0001364854,0.0001466526,0.0001558013,0.0001351651,0.0001778603,0.0001083677,0.0003214893,0.0001413126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001833421,"about_ca_system_score_gemma":0.0001015442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006689184,"about_ca_topic_score_gemma":0.001043305,"domain_scores_codex":[0.9999131,0.000031605,0.000004539613,0.00001708797,0.00001481192,0.00001883337],"domain_scores_gemma":[0.9999369,0.00001810568,0.00001902617,0.000005554518,0.000010408,0.00001000516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001301564,0.0001410501,0.0197626,0.0001302264,0.00004696359,0.0003604582,0.0001087586,0.0001504089,0.9636984,0.0002480391,0.0001658908,0.01388563],"study_design_scores_gemma":[0.00006752082,0.0018193,0.7391185,0.00005616683,0.0001727882,0.00202906,0.000544285,0.002916244,0.2469499,0.0004866685,0.005809623,0.00003011016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953657,0.003001478,0.0004250434,0.000131388,0.00001367825,0.00001116706,0.0002262476,0.00001473788,0.0008104931],"genre_scores_gemma":[0.9958534,0.001985328,0.0008208639,0.00008958462,0.00001801938,0.00001640609,0.0002788242,0.00000648387,0.0009310295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235481,"threshold_uncertainty_score":0.004133105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009980245477016484,"score_gpt":0.2483325590192866,"score_spread":0.2383523135422701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}