{"id":"W2275844848","doi":"10.2174/1570159x13666150630171433","title":"The Involvement of TNF-α in Cognitive Dysfunction Associated with Major Depressive Disorder: An Opportunity for Domain Specific Treatments","year":2015,"lang":"en","type":"review","venue":"Current Neuropharmacology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Major depressive disorder; Adalimumab; Medicine; Cognition; Comorbidity; Clinical psychology; Infliximab; Etanercept; Psychiatry; Bioinformatics; Disease; Internal medicine; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004379672,0.0006451927,0.001288861,0.0003018132,0.000298583,0.00004765532,0.0006255209,0.0001942863,0.00005813184],"category_scores_gemma":[0.0005453127,0.0004282985,0.0002722881,0.0006891993,0.0005384195,0.0001518047,0.0001645156,0.0006314506,0.00001912658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002488303,"about_ca_system_score_gemma":0.0006335112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006578359,"about_ca_topic_score_gemma":0.0001030742,"domain_scores_codex":[0.9948312,0.002226838,0.000849519,0.001021969,0.0004049237,0.0006655668],"domain_scores_gemma":[0.9957429,0.002306473,0.001128722,0.000358871,0.0001877759,0.0002752788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006727573,0.002677697,0.00006632843,0.001110118,0.0001607826,0.00004383086,0.0002296508,0.000004372916,0.0002239437,0.0001341512,0.001789036,0.9928873],"study_design_scores_gemma":[0.007147128,0.001070756,0.0001092518,0.001053818,0.0005235569,0.00001197847,0.0001076519,0.000009379888,0.0001191677,0.0002823437,0.9890994,0.0004656024],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03841615,0.9503539,0.0001409001,0.00005078275,0.002537004,0.007084578,0.001168394,0.00008851833,0.0001598115],"genre_scores_gemma":[0.001974153,0.9953043,0.000007284,0.0001029503,0.0001107992,0.001650455,0.0005918588,0.00009991131,0.0001582802],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9924217,"threshold_uncertainty_score":0.9998169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2044859349534796,"score_gpt":0.4030462794623671,"score_spread":0.1985603445088875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}