{"id":"W2276340295","doi":"10.3310/hta20100","title":"OPTIMA prelim: a randomised feasibility study of personalised care in the treatment of women with early breast cancer","year":2016,"lang":"en","type":"article","venue":"Health Technology Assessment","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Ontario Institute for Cancer Research","funders":"Health Technology Assessment Programme; Medical Research Council; National Institute for Health and Care Research","keywords":"Medicine; Breast cancer; Oncology; Internal medicine; Randomized controlled trial; Chemotherapy; Cancer; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002227041,0.0002035652,0.0004744014,0.00009521821,0.00007533492,0.000002615943,0.0001937858,0.00009965106,0.00001076993],"category_scores_gemma":[0.000006740642,0.000101792,0.00004417197,0.0002180874,0.0002208224,0.000003596592,0.00004021626,0.00005467848,1.993847e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008251256,"about_ca_system_score_gemma":0.0004366739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001185357,"about_ca_topic_score_gemma":0.002303838,"domain_scores_codex":[0.9984957,0.0001922883,0.0003460429,0.000406713,0.0001858448,0.0003734163],"domain_scores_gemma":[0.9989445,0.00003904907,0.0002624163,0.0005714396,0.0001395145,0.00004310787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008850985,0.004147628,0.9447913,0.00007874737,0.0004583713,0.000005481041,0.008777004,0.0000098773,0.001724021,0.00003862012,0.00001810292,0.03109991],"study_design_scores_gemma":[0.03535774,0.01306316,0.9270562,0.00006657567,0.00004562019,0.000009749429,0.02288517,5.925867e-7,0.001271882,0.0000124913,0.0001195805,0.0001112397],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923269,0.001497302,0.00003001637,0.003812631,0.00002631482,0.002125604,0.000142059,0.00001428593,0.00002484342],"genre_scores_gemma":[0.9963745,0.0007584409,0.0002102754,0.00005217309,0.00001716211,0.00255985,0.000005961312,0.00001375984,0.000007829972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03098867,"threshold_uncertainty_score":0.4150959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459447802586401,"score_gpt":0.3372890086815146,"score_spread":0.3226945306556506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}