{"id":"W2276967039","doi":"10.1038/cdd.2016.14","title":"NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis","year":2016,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Child and Family Research Institute; University of Calgary","funders":"National Institutes of Health; Canadian Institutes of Health Research; CH.I.L.D. Foundation; Crohn's and Colitis Canada; Michael Smith Health Research BC; Alberta Innovates - Health Solutions; Kidney Foundation of Canada; Alberta Innovates","keywords":"Inflammasome; Cell biology; Apoptosis; Caspase 8; Caspase; NLRP1; Chemistry; Caspase 1; Caspase 3; Tumor necrosis factor alpha; Pyrin domain; Biology; Molecular biology; Receptor; Programmed cell death; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000453527,0.0001304113,0.000101819,0.00003997589,0.0001305097,0.00002592107,0.00005762677,0.0001402256,0.00001613799],"category_scores_gemma":[0.00002133557,0.00009758144,0.0000747359,0.00002418515,0.0000202904,0.00001533756,0.00003791866,0.00002843764,0.000004781867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001478647,"about_ca_system_score_gemma":0.00002590416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008421444,"about_ca_topic_score_gemma":0.000004414953,"domain_scores_codex":[0.9993206,0.00001019492,0.0001574198,0.0002435758,0.00006242028,0.0002058437],"domain_scores_gemma":[0.9996509,0.00001693967,0.00008338281,0.0001493388,0.00005001479,0.00004942886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002345997,0.00004489628,0.00230632,0.00005109956,0.00001354862,5.382785e-8,0.00004289945,0.000002128224,0.9951552,0.00002605122,0.00007620269,0.002047056],"study_design_scores_gemma":[0.002065569,0.0001579437,0.02979132,0.00001585488,0.00002479613,5.302487e-7,0.00003365338,0.00007543785,0.9669178,0.0001427187,0.0006157703,0.0001585633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925333,0.00007936551,0.006557407,0.00005472801,0.00009416092,0.0002466163,0.00001846216,0.000009511677,0.0004064376],"genre_scores_gemma":[0.9977705,0.0002078378,0.0001388603,0.00003045633,0.0001361532,0.00004953287,0.0002178966,0.00001751369,0.001431202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0282373,"threshold_uncertainty_score":0.3979256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00668375055848677,"score_gpt":0.2027203695735228,"score_spread":0.196036619015036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}