{"id":"W2276967039","doi":"10.1038/cdd.2016.14","title":"NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis","year":2016,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Child and Family Research Institute; University of Calgary","funders":"National Institutes of Health; Canadian Institutes of Health Research; CH.I.L.D. Foundation; Crohn's and Colitis Canada; Michael Smith Health Research BC; Alberta Innovates - Health Solutions; Kidney Foundation of Canada; Alberta Innovates","keywords":"Inflammasome; Cell biology; Apoptosis; Caspase 8; Caspase; NLRP1; Chemistry; Caspase 1; Caspase 3; Tumor necrosis factor alpha; Pyrin domain; Biology; Molecular biology; Receptor; Programmed cell death; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004052994,0.000427446,0.0003263546,0.0003973413,0.0004580587,0.0008925807,0.000378465,0.0006135806,0.002098077],"category_scores_gemma":[0.0003637506,0.0002246553,0.0005896672,0.0002407039,0.0004497336,0.00113552,0.0006454527,0.001261767,0.001012782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001019274,"about_ca_system_score_gemma":0.0003488551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002648162,"about_ca_topic_score_gemma":0.0004406434,"domain_scores_codex":[0.9993941,0.0001050134,0.00005797667,0.0001060846,0.0001233986,0.0002134308],"domain_scores_gemma":[0.9996874,0.0000241467,0.0001161907,0.00003985296,0.00006545295,0.00006701477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005930174,0.00001913651,0.0004697121,0.00004218498,0.000008315007,0.0002000691,0.00003616989,0.00003940734,0.9968275,0.0004528446,0.00008500514,0.001226698],"study_design_scores_gemma":[0.00004619825,0.0001462666,0.02060422,0.00001770169,0.00002477606,0.001119471,0.0001898822,0.0008689547,0.9735839,0.0008153318,0.002570837,0.00001263337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791079,0.00624296,0.01028337,0.0005087735,0.0001234628,0.00004151833,0.0006648824,0.0002530273,0.002774046],"genre_scores_gemma":[0.9950604,0.0006132812,0.00201464,0.00008152911,0.00001729759,0.0000246707,0.0004335431,0.0000307081,0.001723908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002098077,"threshold_uncertainty_score":0.007395327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00668375055848677,"score_gpt":0.2027203695735228,"score_spread":0.196036619015036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}