{"id":"W2277091616","doi":"10.1002/hup.2519","title":"Genetic association analysis of N‐methyl‐<scp>d</scp>‐aspartate receptor subunit gene<i>GRIN2B</i>and clinical response to clozapine","year":2016,"lang":"en","type":"article","venue":"Human Psychopharmacology Clinical and Experimental","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Genentech; Sunovion; Eisai; Sanofi; National Alliance for Research on Schizophrenia and Depression; GlaxoSmithKline; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Clozapine; Schizophrenia (object-oriented programming); Glutamate receptor; Atypical antipsychotic; Medicine; Internal medicine; Antipsychotic; Pharmacology; Receptor; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002684907,0.0003088435,0.0008559588,0.0005325551,0.0003635263,0.00004260473,0.0005381863,0.0002820986,0.0004787758],"category_scores_gemma":[0.002507459,0.0002403344,0.0003309688,0.0009308193,0.001535127,0.0001690844,0.0004312066,0.0004989952,0.0001737072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005061395,"about_ca_system_score_gemma":0.00006726027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000615514,"about_ca_topic_score_gemma":0.000003597593,"domain_scores_codex":[0.9925931,0.003394782,0.00140468,0.001430281,0.0004731639,0.0007040013],"domain_scores_gemma":[0.990044,0.008327481,0.0004338537,0.0003410603,0.00009302078,0.0007606138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00239703,0.0008118781,0.09038764,0.000003453889,0.0001876402,0.0000484592,0.0001503653,0.000001583887,0.8988861,0.00001692083,0.005908043,0.001200867],"study_design_scores_gemma":[0.008898113,0.003436041,0.1826923,0.000009167892,0.0003962616,0.00001153934,0.00004525796,0.00008573625,0.7855737,0.0000400861,0.01861765,0.0001942148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960378,0.0001761224,0.000009240496,0.001443845,0.00155082,0.0005339106,0.00009412588,0.00006460948,0.00008953399],"genre_scores_gemma":[0.9892924,0.002014698,0.00007973053,0.005905781,0.0002915333,0.00007486103,0.000001263852,0.00003141471,0.002308248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1133125,"threshold_uncertainty_score":0.9800553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09698878444911962,"score_gpt":0.47350505035859,"score_spread":0.3765162659094704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}