{"id":"W2277251767","doi":"10.1096/fasebj.22.2_supplement.604","title":"Conditional expression of Ang‐2 during tumor angiogenesis: tightly balanced Angiopoietin/Tie2 signaling determines the tumor vascular phenotype","year":2008,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Angiopoietin receptor; Angiogenesis; Angiopoietin; Genetically modified mouse; Lewis lung carcinoma; Paracrine signalling; Pericyte; Cancer research; Neovascularization; Transgene; Vascular permeability; Biology; Cell biology; Vascular endothelial growth factor; Pathology; Endothelial stem cell; Immunology; Endocrinology; Medicine; Internal medicine; Receptor; Gene; Cancer; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490842,0.0002665884,0.0002054605,0.0002149474,0.0001679905,0.0003126209,0.0001881699,0.0002271373,0.001167382],"category_scores_gemma":[0.0001085116,0.0001977881,0.0001423725,0.0001548623,0.0003174573,0.0002215061,0.0002505475,0.000568175,0.0003173054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003609701,"about_ca_system_score_gemma":0.00027136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006835067,"about_ca_topic_score_gemma":0.001492187,"domain_scores_codex":[0.9998119,0.00003333457,0.00001609871,0.00004141128,0.00004399845,0.00005328273],"domain_scores_gemma":[0.9998367,0.00002817055,0.00004159393,0.00001827898,0.000009188951,0.00006605819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006794772,0.00002191421,0.00007941683,0.000006794192,0.000001263846,0.00003785274,0.000009311391,0.00003364118,0.9993883,0.0001129324,0.00001346312,0.0002270909],"study_design_scores_gemma":[0.0000202557,0.0001970418,0.002184223,0.00000343378,0.000008841021,0.0002802294,0.00002012987,0.001226585,0.9942651,0.00005159724,0.001736706,0.00000570466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953364,0.0004302966,0.002467307,0.00004805944,0.00002112226,0.00004017638,0.0003938878,0.000060302,0.001202592],"genre_scores_gemma":[0.9929659,0.0003360358,0.002750624,0.00003522469,0.000009856495,0.00005430381,0.0004954615,0.00004562572,0.003306969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001167382,"threshold_uncertainty_score":0.003905296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128415888013113,"score_gpt":0.2276586252726529,"score_spread":0.2148170364713416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}