{"id":"W2277396963","doi":"10.1016/s1473-3099(16)00052-9","title":"Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial","year":2016,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Hepatitis C virus research","field":"Medicine","cited_by":446,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Vancouver General Hospital","funders":"Astellas Pharma; Alnylam Pharmaceuticals; Gilead Sciences; Cilag; GlaxoSmithKline","keywords":"Sofosbuvir; Ribavirin; Ledipasvir; Medicine; Hepatitis C virus; Open label; Genotype; Internal medicine; Hepatitis C; Virology; Clinical trial; Virus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002379322,0.002936759,0.003804133,0.0005734679,0.0004388688,0.001296071,0.001236917,0.002271351,0.007893747],"category_scores_gemma":[0.002154152,0.001160844,0.00292182,0.0005160155,0.001647956,0.001877748,0.0007706232,0.004045481,0.001317317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001208921,"about_ca_system_score_gemma":0.001305826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001252531,"about_ca_topic_score_gemma":0.002576233,"domain_scores_codex":[0.9989138,0.0006281169,0.00005486378,0.0001543525,0.00005348722,0.0001953737],"domain_scores_gemma":[0.9992087,0.0002607818,0.0001307985,0.00006995732,0.00004045153,0.0002892014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9884692,0.001846335,0.0002775841,0.0003952875,0.0005793159,0.00003274315,0.0000422131,0.0002504649,0.001011304,0.00007391988,0.0003951188,0.006626641],"study_design_scores_gemma":[0.9798285,0.01894887,0.0004226134,0.00001660378,0.0001683905,0.00001606109,0.00001567233,0.0001712384,0.00007920565,0.00009653783,0.0002261068,0.00001012975],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848468,0.005998246,0.0008264135,0.001061185,0.0009436759,0.002809781,0.001237714,0.000205376,0.002070737],"genre_scores_gemma":[0.983579,0.003147634,0.00210589,0.001297548,0.0004678357,0.0037208,0.001508808,0.00003958411,0.004132894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007893747,"threshold_uncertainty_score":0.02640718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03944632335243386,"score_gpt":0.343084737303476,"score_spread":0.3036384139510421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}