{"id":"W2277396963","doi":"10.1016/s1473-3099(16)00052-9","title":"Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial","year":2016,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Hepatitis C virus research","field":"Medicine","cited_by":446,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Vancouver General Hospital","funders":"Astellas Pharma; Alnylam Pharmaceuticals; Gilead Sciences; Cilag; GlaxoSmithKline","keywords":"Sofosbuvir; Ribavirin; Ledipasvir; Medicine; Hepatitis C virus; Open label; Genotype; Internal medicine; Hepatitis C; Virology; Clinical trial; Virus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002922927,0.0003077215,0.0007036312,0.0001653795,0.000239491,0.000132011,0.0001528598,0.00007289738,0.0002520035],"category_scores_gemma":[0.001503998,0.0001601013,0.0000393518,0.0003133764,0.000332963,0.0005294939,0.0002412173,0.0002140804,0.00003643925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002584178,"about_ca_system_score_gemma":0.0003282503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002263054,"about_ca_topic_score_gemma":0.006613666,"domain_scores_codex":[0.9977558,0.0003970581,0.0003555149,0.0005162736,0.0004411419,0.0005342533],"domain_scores_gemma":[0.9981,0.0006269222,0.0001479171,0.0004982417,0.0001637508,0.0004632133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3454421,0.001589454,0.55989,0.000110733,0.0001118243,0.00008701929,0.00008323525,0.000003061572,0.00006190064,0.00001748416,0.0002951339,0.09230806],"study_design_scores_gemma":[0.5109402,0.002503584,0.4832252,0.0002946814,0.0002240564,0.00000406725,0.000002412138,0.0002170378,0.00002458405,0.0000576239,0.002284376,0.0002222021],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926514,0.000770728,0.0001000232,0.0002537703,0.000131548,0.005353727,0.0003669083,0.0001300869,0.0002417964],"genre_scores_gemma":[0.9876868,0.01045425,0.00003712574,0.0004124661,0.0002751118,0.0008035385,0.00005114578,0.00005299956,0.0002265615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1654982,"threshold_uncertainty_score":0.6528741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03944632335243386,"score_gpt":0.343084737303476,"score_spread":0.3036384139510421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}