{"id":"W2277827736","doi":"10.1186/s13058-015-0668-y","title":"Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer","year":2016,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Canada Research Chairs; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cure Brain Cancer Foundation; Canadian Cancer Society","keywords":"Claudin; PTEN; Breast cancer; Basal (medicine); Surgical oncology; Cancer research; Epithelium; Medicine; Biology; Internal medicine; Oncology; Cancer; Pathology; Tight junction; Genetics; Apoptosis; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004243388,0.0003388194,0.000325733,0.0002861949,0.0002392807,0.00006619055,0.0003247509,0.0002595996,0.0001330388],"category_scores_gemma":[0.00005929963,0.0002543921,0.00007332951,0.0004039199,0.0004002336,0.00005309504,0.0004075232,0.0002569202,0.00001861527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006131653,"about_ca_system_score_gemma":0.0006678724,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007265945,"about_ca_topic_score_gemma":0.004363721,"domain_scores_codex":[0.9970408,0.0003268415,0.0003208675,0.0009162858,0.0005632287,0.0008319547],"domain_scores_gemma":[0.9984927,0.00007221547,0.0001772601,0.0004413701,0.0006055945,0.0002108816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00549149,0.0003672934,0.07297772,0.0002660184,0.0006442401,0.0001731453,0.000833205,0.0000867126,0.6505597,0.00007797779,0.006886941,0.2616356],"study_design_scores_gemma":[0.007302153,0.0002037538,0.8618066,0.0009730404,0.00004697416,0.0003584106,0.0004740459,0.00009867192,0.1264922,0.0002737518,0.001146202,0.0008241797],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802957,0.005669707,0.0001156691,0.01148429,0.000211327,0.0005770588,0.001506071,0.00003432692,0.0001058206],"genre_scores_gemma":[0.9882391,0.008753664,0.00006615321,0.0002544853,0.0005287969,0.001099329,0.0000910429,0.00006428518,0.000903155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7888289,"threshold_uncertainty_score":0.9999908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093588302279407,"score_gpt":0.3234559164193789,"score_spread":0.3025200333965848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}