{"id":"W2278042283","doi":"10.1093/rheumatology/kev089.104","title":"217. Long-Term (104-Week) Efficacy and Safety Profile of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, in Patients with Psoriatic Arthritis: Results from a Phase III, Randomized, Controlled Trial and Open-Label Extension (PALACE 1)","year":2015,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Apremilast; Medicine; Open label; Psoriatic arthritis; Randomized controlled trial; Internal medicine; Dermatology; Arthritis; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001515396,0.0007977704,0.001557106,0.00024651,0.0002975536,0.0006586246,0.0005968417,0.001263475,0.006069934],"category_scores_gemma":[0.001528452,0.0004408928,0.001827152,0.000297829,0.0005217022,0.0006248969,0.0002308611,0.002302748,0.001436827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004128534,"about_ca_system_score_gemma":0.0006579144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003731409,"about_ca_topic_score_gemma":0.0008235929,"domain_scores_codex":[0.9993367,0.0002992447,0.00008506207,0.0001078825,0.0000838851,0.00008724102],"domain_scores_gemma":[0.9988199,0.0003087934,0.0003939596,0.0001009582,0.0001196192,0.0002566589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9025807,0.01275832,0.002696336,0.001296212,0.001212823,0.0001122748,0.00005734985,0.0005616034,0.0138709,0.00005652036,0.002166516,0.06263055],"study_design_scores_gemma":[0.6287882,0.3427728,0.0196611,0.00007927473,0.001158259,0.000195424,0.00002795136,0.0005494781,0.004580705,0.0001103471,0.002048824,0.00002766795],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855443,0.007071654,0.0004591852,0.0005696707,0.0003097152,0.001505862,0.001861191,0.0001149255,0.002563488],"genre_scores_gemma":[0.9876226,0.002370561,0.001364915,0.001106485,0.0003665636,0.001527559,0.002593604,0.00002518063,0.003022599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006069934,"threshold_uncertainty_score":0.02030593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05484668841253543,"score_gpt":0.352832666363424,"score_spread":0.2979859779508886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}