{"id":"W2278042283","doi":"10.1093/rheumatology/kev089.104","title":"217. Long-Term (104-Week) Efficacy and Safety Profile of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, in Patients with Psoriatic Arthritis: Results from a Phase III, Randomized, Controlled Trial and Open-Label Extension (PALACE 1)","year":2015,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Apremilast; Medicine; Open label; Psoriatic arthritis; Randomized controlled trial; Internal medicine; Dermatology; Arthritis; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001833098,0.0003053977,0.002181763,0.00006597536,0.00009403112,0.00008385182,0.0001141168,0.0001198212,0.00002737048],"category_scores_gemma":[0.002045093,0.0002034854,0.00004705858,0.0001518938,0.0002271693,0.000478813,0.0002129938,0.0003000816,0.000002141396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004578208,"about_ca_system_score_gemma":0.0001105491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004927415,"about_ca_topic_score_gemma":0.0001647781,"domain_scores_codex":[0.9970807,0.0005712578,0.001041109,0.0005504628,0.0004443219,0.0003121495],"domain_scores_gemma":[0.9972213,0.00132924,0.0005105434,0.000320249,0.0002303711,0.0003882841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9690302,0.005352559,0.002566356,0.00003375712,0.000333895,0.00007228748,0.001015164,0.00000115842,0.00007619514,0.000005259635,0.0002383447,0.0212748],"study_design_scores_gemma":[0.9848625,0.006001791,0.006280328,0.0006826544,0.0006954381,0.000005373384,0.0001211596,0.0007086385,0.0001253427,0.00002553196,0.0002538981,0.0002373464],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855351,0.0046695,0.00002286713,0.0004212367,0.000258976,0.00865032,0.0001605628,0.00002446173,0.0002569346],"genre_scores_gemma":[0.9971895,0.001077454,0.0007914085,0.0002453728,0.0001650066,0.0002039932,0.0002351339,0.00002567523,0.00006643203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02103745,"threshold_uncertainty_score":0.8297893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05484668841253543,"score_gpt":0.352832666363424,"score_spread":0.2979859779508886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}