{"id":"W2278045636","doi":"10.1128/msphere.00015-15","title":"The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity","year":2015,"lang":"en","type":"article","venue":"mSphere","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Else Kröner-Fresenius-Stiftung; Deutsche Forschungsgemeinschaft; Wilhelm Sander-Stiftung; Bar-Ilan University; Government of Canada; McGill University","keywords":"Ubiquitin ligase; Ubiquitin; DNA ligase; Cell biology; E2F; Adenoviridae; Function (biology); Chemistry; Biology; Molecular biology; DNA; Biochemistry; Cell cycle; Cell; Gene; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004161327,0.0001735792,0.0001295332,0.00001486842,0.0003473028,0.00007710981,0.0003510524,0.0001253917,0.0004223504],"category_scores_gemma":[0.00006653628,0.0001343042,0.00007707723,0.0001309753,0.0002084612,0.000006358066,0.0001658104,0.0001851316,0.0002376316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000411282,"about_ca_system_score_gemma":0.0003229599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006470361,"about_ca_topic_score_gemma":0.001929579,"domain_scores_codex":[0.9986086,0.00018346,0.0001496558,0.0003425355,0.0003413145,0.0003744605],"domain_scores_gemma":[0.9990123,0.00002629794,0.0000710727,0.0005013301,0.0002206375,0.0001683717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001422497,0.00008784371,0.0005672719,0.00000680274,0.00007069258,0.000003694497,0.0000212569,0.000050623,0.9444392,0.0001054111,0.04403597,0.009188679],"study_design_scores_gemma":[0.0007543832,0.001899759,0.002789457,0.000006481831,0.000009880301,0.000008080264,0.0001489669,0.00003611356,0.8100969,0.0002874354,0.1837434,0.0002192253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888785,0.001637312,0.00006418971,0.0007027341,0.0002354467,0.0001433299,0.00001812291,0.00002756278,0.008292771],"genre_scores_gemma":[0.9903558,0.00009759186,0.00005242362,0.0003079007,0.0007097753,0.00003208291,0.0000890957,0.00003201662,0.008323288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1397074,"threshold_uncertainty_score":0.5476768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07651860917429626,"score_gpt":0.3426550338365911,"score_spread":0.2661364246622949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}