{"id":"W2278045636","doi":"10.1128/msphere.00015-15","title":"The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity","year":2015,"lang":"en","type":"article","venue":"mSphere","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Else Kröner-Fresenius-Stiftung; Deutsche Forschungsgemeinschaft; Wilhelm Sander-Stiftung; Bar-Ilan University; Government of Canada; McGill University","keywords":"Ubiquitin ligase; Ubiquitin; DNA ligase; Cell biology; E2F; Adenoviridae; Function (biology); Chemistry; Biology; Molecular biology; DNA; Biochemistry; Cell cycle; Cell; Gene; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002809713,0.0004678614,0.0003044849,0.0003162605,0.000186813,0.0004797003,0.000153322,0.0002442263,0.002438065],"category_scores_gemma":[0.0001446407,0.0001576571,0.0005075497,0.0001439345,0.0001733387,0.0002559837,0.0003993456,0.0004292435,0.0007508672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005068622,"about_ca_system_score_gemma":0.0001791084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007130393,"about_ca_topic_score_gemma":0.0006561783,"domain_scores_codex":[0.9997815,0.0000362566,0.00002773223,0.00005194312,0.00004957123,0.00005294811],"domain_scores_gemma":[0.9999171,0.00001281853,0.00001905992,0.00001407835,0.00001270287,0.00002416478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001774268,0.000040071,0.0003124853,0.00003181152,0.000008869777,0.00001926452,0.000008725638,0.00003791929,0.9978216,0.0001042726,0.00004146077,0.001396028],"study_design_scores_gemma":[0.00001336033,0.0002296058,0.003952065,0.000003464603,0.00001401125,0.0001429608,0.000010401,0.0005725156,0.9926589,0.00002968729,0.002368648,0.0000044356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924396,0.002013899,0.003129802,0.00006753928,0.00004433649,0.00002743318,0.0002667684,0.00008877643,0.001921707],"genre_scores_gemma":[0.9931368,0.0004789014,0.00279848,0.0000241676,0.000006569683,0.000009802092,0.0004207734,0.00001566902,0.003108908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002438065,"threshold_uncertainty_score":0.00815618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07651860917429626,"score_gpt":0.3426550338365911,"score_spread":0.2661364246622949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}