{"id":"W2278095550","doi":"10.3389/fcell.2015.00087","title":"The TAK1→IKKβ→TPL2→MKK1/MKK2 Signaling Cascade Regulates IL-33 Expression in Cystic Fibrosis Airway Epithelial Cells Following Infection by Pseudomonas aeruginosa","year":2016,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Consejo Nacional de Ciencia y Tecnología; Consejo Nacional de Ciencia y Tecnología, Guatemala; Cystic Fibrosis Canada; Canadian Institutes of Health Research; McGill University Health Centre; University of Dundee","keywords":"Pseudomonas aeruginosa; Cystic fibrosis; Signal transduction; Airway; Cancer research; Medicine; Cell biology; Biology; Microbiology; Bacteria; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005345038,0.0003614851,0.0004652664,0.0002136249,0.0004749411,0.00002350638,0.0002250108,0.0006026548,0.00004393513],"category_scores_gemma":[0.00008993466,0.0002304414,0.00009937916,0.0002109452,0.0003943431,0.0001543179,0.0001843671,0.0003233022,0.00008331356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002020258,"about_ca_system_score_gemma":0.000107841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002113142,"about_ca_topic_score_gemma":0.00008278093,"domain_scores_codex":[0.9975548,0.0004245792,0.0005837451,0.0006177683,0.00005039291,0.0007687457],"domain_scores_gemma":[0.999173,0.0004238733,0.000158744,0.0001688063,0.00002402597,0.00005159276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002866156,0.00006761775,0.03576015,0.00001895452,0.00004321691,0.0000081021,0.000793161,0.000001952147,0.9406325,0.000009223516,0.01076035,0.01161812],"study_design_scores_gemma":[0.00202897,0.0001611035,0.001823954,0.000117589,0.00001441011,0.00001822583,0.0005764184,0.000003033785,0.8871712,0.0005678436,0.1071596,0.0003576748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900684,0.003111513,0.001846918,0.00006497205,0.00333199,0.0003491316,0.0006420005,0.0000569339,0.0005280799],"genre_scores_gemma":[0.9941196,0.001876058,0.001838505,0.0000776135,0.00004696517,0.00008358686,0.0001516856,0.00002527957,0.001780687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09639922,"threshold_uncertainty_score":0.9397129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0048673801137991,"score_gpt":0.1891943936109405,"score_spread":0.1843270134971414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}