{"id":"W2278095550","doi":"10.3389/fcell.2015.00087","title":"The TAK1→IKKβ→TPL2→MKK1/MKK2 Signaling Cascade Regulates IL-33 Expression in Cystic Fibrosis Airway Epithelial Cells Following Infection by Pseudomonas aeruginosa","year":2016,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Consejo Nacional de Ciencia y Tecnología; Consejo Nacional de Ciencia y Tecnología, Guatemala; Cystic Fibrosis Canada; Canadian Institutes of Health Research; McGill University Health Centre; University of Dundee","keywords":"Pseudomonas aeruginosa; Cystic fibrosis; Signal transduction; Airway; Cancer research; Medicine; Cell biology; Biology; Microbiology; Bacteria; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001440674,0.0003606239,0.0002447405,0.0002007647,0.0002825444,0.0002960006,0.0001161062,0.0002450527,0.00129381],"category_scores_gemma":[0.000109272,0.0001340633,0.0003207435,0.0000899746,0.0001804472,0.0002326232,0.000224055,0.0007577293,0.0003712991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002351522,"about_ca_system_score_gemma":0.0002166971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003934088,"about_ca_topic_score_gemma":0.0004360962,"domain_scores_codex":[0.999835,0.0000294162,0.00001561547,0.00002290119,0.00003636278,0.00006064426],"domain_scores_gemma":[0.999944,0.000007327374,0.00001515423,0.000004291516,0.00001150673,0.00001771832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003179352,0.00004166074,0.0003702854,0.00008111606,0.000004075446,0.00009117281,0.0000377482,0.000064643,0.9980513,0.00005547806,0.00005393404,0.0008307675],"study_design_scores_gemma":[0.00009019811,0.0007007665,0.04583633,0.00003587074,0.00004560389,0.0007238877,0.0002588174,0.002404918,0.9460574,0.0002022996,0.003625877,0.00001799888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925833,0.003259293,0.002127863,0.0002105113,0.0000532456,0.000043608,0.0003587608,0.00004645072,0.001317018],"genre_scores_gemma":[0.9962864,0.001138498,0.001146879,0.0000994956,0.00001893935,0.00007993193,0.0002831542,0.00000722086,0.0009394485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129381,"threshold_uncertainty_score":0.004328191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0048673801137991,"score_gpt":0.1891943936109405,"score_spread":0.1843270134971414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}