{"id":"W2278247833","doi":"10.1371/journal.pone.0148762","title":"Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Paul Scherrer Institut; Ontario Ministry of Economic Development and Innovation; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Allosteric regulation; Effector; Ubiquitin; Biology; Cell biology; Plasma protein binding; Gene; Computational biology; Chemistry; Genetics; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008941258,0.0002666171,0.0002270211,0.0001013914,0.0002759618,0.0003239846,0.0003628702,0.0005435536,0.001659478],"category_scores_gemma":[0.000234059,0.0001809977,0.0003485225,0.0001336199,0.0002674729,0.0003327679,0.0002428355,0.001073587,0.0002694237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000384141,"about_ca_system_score_gemma":0.0003140632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008379291,"about_ca_topic_score_gemma":0.0006629353,"domain_scores_codex":[0.9999504,0.000007282181,0.000002639308,0.00001390683,0.00001075965,0.00001500898],"domain_scores_gemma":[0.9999202,0.00001690735,0.0000198121,0.000006592446,0.00001121092,0.00002527326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007999289,0.0002901658,0.007002635,0.0002752781,0.00007209914,0.001570063,0.0003621012,0.004230218,0.9692291,0.007472028,0.001198818,0.007497561],"study_design_scores_gemma":[0.0006439456,0.001388566,0.05728308,0.00007291131,0.00019049,0.003937338,0.0007623048,0.08670964,0.8174984,0.009281217,0.02210486,0.0001271939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923133,0.0006886882,0.003310848,0.0002435041,0.00003924897,0.00002196932,0.0001168361,0.00009637477,0.003169131],"genre_scores_gemma":[0.9955356,0.0002497887,0.002772792,0.0001026231,0.000004806184,0.000009260399,0.0002752983,0.000009323599,0.001040587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001659478,"threshold_uncertainty_score":0.005551517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02306468993409085,"score_gpt":0.2325486453901192,"score_spread":0.2094839554560283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}