{"id":"W2278978291","doi":"10.1016/j.cyto.2016.01.006","title":"Imbalanced production of IL-18 and its antagonist in human diseases, and its implications for HIV-1 infection","year":2016,"lang":"en","type":"review","venue":"Cytokine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"CARE Canada; Centre Hospitalier de l’Université de Montréal; Institute of Infection and Immunity; McGill University Health Centre; Université de Montréal; Université du Québec à Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Inflammasome; Antagonist; Cytokine; Interleukin 1 receptor antagonist; Pathogenesis; Immunology; Caspase 1; Biology; Receptor antagonist; Medicine; Pharmacology; Receptor; Inflammation; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005603106,0.0006727182,0.001213795,0.001301083,0.0002016086,0.0009732248,0.0006302119,0.0009122408,0.001872217],"category_scores_gemma":[0.0007278562,0.0002263677,0.0003279252,0.001394866,0.0004296516,0.001082125,0.0006339913,0.001459732,0.001008871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004021584,"about_ca_system_score_gemma":0.001025727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007544635,"about_ca_topic_score_gemma":0.001485997,"domain_scores_codex":[0.9998521,0.00002320684,0.00002882227,0.00002529468,0.0000555335,0.00001507792],"domain_scores_gemma":[0.9998099,0.00007757929,0.000034736,0.000005330505,0.00005274247,0.00001976063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002191896,0.00006989005,0.0003383147,0.01982314,0.0001204307,0.000393737,0.00005887932,0.0003623652,0.003315135,0.00371078,0.03349018,0.9380981],"study_design_scores_gemma":[0.00004541511,0.00008622656,0.001084586,0.003201335,0.0001773938,0.001857347,0.00007443743,0.00009936303,0.0007769914,0.002384895,0.9901882,0.00002385504],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001070248,0.9991374,0.00007292764,0.000190896,0.0001422328,0.000002294359,0.000016085,0.000002807786,0.0003283746],"genre_scores_gemma":[0.0006382823,0.9986118,0.0001332104,0.0001339346,0.0001700628,0.000004298718,0.00002162928,7.810381e-7,0.0002859489],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001872217,"threshold_uncertainty_score":0.006263196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02115504989618481,"score_gpt":0.3170351351613939,"score_spread":0.295880085265209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}