{"id":"W2279060238","doi":"10.1371/journal.pone.0150175","title":"Solar Simulated Ultraviolet Radiation Induces Global Histone Hypoacetylation in Human Keratinocytes","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Skin Protection and Aging","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institutes of Health; York University; NYU Langone Medical Center","keywords":"Histone H4; Acetylation; Histone H3; Histone; Histone deacetylase; Chromatin; Histone Acetyltransferases; Histone H2A; Lysine; Cell biology; Histone acetyltransferase; Histone deacetylase 2; Biology; Chemistry; Biochemistry; DNA; Gene; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365548,0.00009306026,0.0001799842,0.00008918424,0.00006689386,0.00001297902,0.00003506972,0.00008932362,0.0001910008],"category_scores_gemma":[0.0002159926,0.00007253763,0.00002649818,0.000194406,0.00002750698,0.0001300404,0.000009379681,0.0001011285,0.00005360723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002814251,"about_ca_system_score_gemma":0.00002548488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008222253,"about_ca_topic_score_gemma":0.00001196501,"domain_scores_codex":[0.9991651,0.00004639133,0.0002255054,0.0001875582,0.0002260686,0.0001494343],"domain_scores_gemma":[0.9996307,0.00003637844,0.00007591538,0.0001335707,0.00006329422,0.00006014886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005974248,0.0005429561,0.06811621,0.00003001972,0.00004895767,0.000006669777,0.0001193614,0.000009822002,0.9199218,0.00008580145,0.00003100434,0.01102762],"study_design_scores_gemma":[0.003921677,0.0002006072,0.2861275,0.0006844628,0.00008312253,0.000006007015,0.00003836383,0.0008909057,0.7073389,0.0004631587,0.00007028999,0.0001750386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968199,0.0001392793,0.0002374402,0.001333888,0.00003527903,0.0003516384,0.000004476761,0.0001160964,0.0009620254],"genre_scores_gemma":[0.9988704,0.00002328944,0.0003285766,0.0001953443,0.000144158,0.00001170756,0.00002259258,0.00001075719,0.0003931488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2180113,"threshold_uncertainty_score":0.2957999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04624942350919298,"score_gpt":0.2932298513734354,"score_spread":0.2469804278642424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}