{"id":"W2279327176","doi":"10.1016/j.ejmech.2016.02.049","title":"Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry","year":2016,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":179,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"University of Waterloo; Ontario Ministry of Research, Innovation and Science; Ontario Mental Health Foundation","keywords":"Chemistry; Amyloid (mycology); Amyloid beta; Biochemistry of Alzheimer's disease; Senile plaques; Small molecule; Drug discovery; Dementia; Alzheimer's disease; Pharmacology; Neurodegeneration; Neuroscience; Biochemistry; Amyloid precursor protein; Disease; Medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001928769,0.0009093563,0.002861441,0.0003134357,0.0000587529,0.00002538413,0.0007942329,0.0002101928,0.001807655],"category_scores_gemma":[0.0009514123,0.0005859808,0.0007529531,0.0006104248,0.0004636415,0.000211404,0.0001737462,0.00235422,0.0001141766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007791035,"about_ca_system_score_gemma":0.002814265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002231303,"about_ca_topic_score_gemma":7.06378e-7,"domain_scores_codex":[0.9934227,0.0005534878,0.002397531,0.0007254478,0.001938645,0.0009621687],"domain_scores_gemma":[0.9950597,0.0003186805,0.001401671,0.0006977341,0.0003144206,0.002207796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00110518,0.0006865243,0.0003539929,0.01141864,0.002905495,0.06541143,0.00003981406,5.201682e-7,0.00002419316,5.203075e-7,0.00118305,0.9168707],"study_design_scores_gemma":[0.005829331,0.0002718432,0.0003101957,0.113731,0.00410112,0.004436523,0.00009743538,0.000001001389,0.0001099958,0.00001528116,0.8706046,0.0004916496],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000257553,0.9865357,0.000004655261,0.0005390589,0.0002039315,0.0004607597,0.00007912041,0.00002243506,0.01189679],"genre_scores_gemma":[0.002089367,0.9949598,0.00004439305,0.00007364309,0.002361419,0.00002047249,0.0001434352,0.0001581239,0.0001493981],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.916379,"threshold_uncertainty_score":0.9999474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04297715630599256,"score_gpt":0.357956543770925,"score_spread":0.3149793874649324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}