{"id":"W2279569345","doi":"10.1089/hum.2015.108","title":"Long-Term Expression of the Human <i>CFTR</i> Gene in Mouse Airway via Helper-Dependent Adenoviral Vector Delivery and Transient Immunosuppression","year":2015,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Genetic enhancement; Immunosuppression; Transgene; Viral vector; Immune system; Biology; Gene delivery; Immunology; Azathioprine; Reporter gene; CTL*; Gene expression; Cancer research; Medicine; Gene; Internal medicine; CD8; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003649215,0.0003504297,0.0002848773,0.0002325057,0.0001693817,0.0003985798,0.0002920394,0.0004208349,0.0007110955],"category_scores_gemma":[0.000118041,0.0001765772,0.0003496475,0.0001602233,0.0003966105,0.0003781423,0.0001656684,0.0009222874,0.0002840721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003198299,"about_ca_system_score_gemma":0.0002948475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005687442,"about_ca_topic_score_gemma":0.000884335,"domain_scores_codex":[0.9997144,0.00004245152,0.00003475193,0.00006653172,0.00006637176,0.00007538527],"domain_scores_gemma":[0.9998123,0.00004116017,0.00005935288,0.00003102515,0.00001770106,0.00003836121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003310148,0.00001675974,0.00003793312,0.00001128747,0.000001241227,0.00001292757,0.000007298324,0.00001740281,0.9994527,0.00004337068,0.000008631933,0.0003574464],"study_design_scores_gemma":[0.00001089505,0.0003131655,0.0005026851,0.000003588279,0.0000100745,0.00008395761,0.0000105835,0.000208956,0.9980965,0.0000164555,0.0007409611,0.000002142353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863015,0.002653368,0.009166944,0.000155152,0.00006120429,0.00009534813,0.0003344193,0.0001729274,0.001059095],"genre_scores_gemma":[0.9856809,0.001822784,0.009096568,0.0000660885,0.0000225961,0.0001186208,0.0005399553,0.0000472302,0.002605284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007110955,"threshold_uncertainty_score":0.002378821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02899727298165551,"score_gpt":0.2924955363491076,"score_spread":0.2634982633674521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}