{"id":"W2279569345","doi":"10.1089/hum.2015.108","title":"Long-Term Expression of the Human <i>CFTR</i> Gene in Mouse Airway via Helper-Dependent Adenoviral Vector Delivery and Transient Immunosuppression","year":2015,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Genetic enhancement; Immunosuppression; Transgene; Viral vector; Immune system; Biology; Gene delivery; Immunology; Azathioprine; Reporter gene; CTL*; Gene expression; Cancer research; Medicine; Gene; Internal medicine; CD8; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004602644,0.0002960426,0.0002801792,0.0001003199,0.0001873319,0.00003193194,0.0005821017,0.0002128213,0.000069922],"category_scores_gemma":[0.000005785844,0.0002225113,0.0001321919,0.0001045445,0.000217602,0.00001320159,0.0002171953,0.0002234985,0.000003637783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005445755,"about_ca_system_score_gemma":0.00009520097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008242299,"about_ca_topic_score_gemma":0.0002855532,"domain_scores_codex":[0.9978016,0.0004010012,0.0004062257,0.0005160639,0.0004683364,0.0004067473],"domain_scores_gemma":[0.9987323,0.000008519904,0.0001366938,0.0008579371,0.0001185602,0.0001460014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001698251,0.0003018684,0.004661292,0.00001523788,0.00003966139,0.000007840893,0.0006685163,0.0001035251,0.9900269,9.202633e-7,0.000119537,0.002356475],"study_design_scores_gemma":[0.00370572,0.002341239,0.01451091,0.00003375912,0.000006406947,0.00001453888,0.000042973,0.000006155355,0.9789521,0.00001826382,0.0001125972,0.0002553439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905105,0.008592259,0.00006244086,0.00004838211,0.00009143855,0.0005981432,0.00002871209,0.0000153515,0.00005274261],"genre_scores_gemma":[0.9979119,0.0009788527,0.00004423449,0.0001427504,0.0001657521,0.00005762373,0.0000864102,0.00006537917,0.0005471118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01107479,"threshold_uncertainty_score":0.9073748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02899727298165551,"score_gpt":0.2924955363491076,"score_spread":0.2634982633674521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}