{"id":"W2279595299","doi":"10.1016/j.jmb.2016.02.020","title":"Autoinhibition of ETV6 DNA Binding Is Established by the Stability of Its Inhibitory Helix","year":2016,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of General Medical Sciences; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Helix (gastropod); Chemistry; DNA-binding domain; Biophysics; DNA; Stereochemistry; Circular dichroism; Steric effects; Crystallography; Biochemistry; Biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001890066,0.0002471143,0.0002566727,0.0001947892,0.0002679446,0.0005390281,0.0004079784,0.0003180614,0.003276517],"category_scores_gemma":[0.0003390848,0.0001941193,0.0002524242,0.00009558183,0.0003265167,0.0002738519,0.0003640899,0.0007997074,0.0009605564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004005761,"about_ca_system_score_gemma":0.0001767785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006388543,"about_ca_topic_score_gemma":0.0005644643,"domain_scores_codex":[0.9997935,0.00002600794,0.00001270646,0.00005242402,0.00005095732,0.00006439097],"domain_scores_gemma":[0.9997278,0.00005552501,0.00004714666,0.00003492737,0.00003214641,0.0001023924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001793674,0.00001539382,0.0003437536,0.00001243324,0.000005646585,0.00003868464,0.000006917087,0.0001083373,0.9981799,0.0002822136,0.00003443421,0.0007931259],"study_design_scores_gemma":[0.00001943709,0.00007301949,0.006894619,0.000004908662,0.000006390286,0.0002014271,0.00002085506,0.002566378,0.9886788,0.0001694493,0.001357334,0.000007449778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943883,0.0007141039,0.00270713,0.00005460554,0.00002883182,0.000008319059,0.0001313722,0.0000835238,0.001883853],"genre_scores_gemma":[0.9987012,0.00005656081,0.0003126901,0.00002031364,0.000004368074,0.000003431684,0.0001275145,0.00001726176,0.0007565242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003276517,"threshold_uncertainty_score":0.01096106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006670848909797461,"score_gpt":0.2334305338297077,"score_spread":0.2267596849199102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}