{"id":"W2279650146","doi":"10.1007/s10863-016-9650-3","title":"Modulation of mitochondrial ion transport by inorganic polyphosphate - essential role in mitochondrial permeability transition pore","year":2016,"lang":"en","type":"article","venue":"Journal of Bioenergetics and Biomembranes","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Leverhulme Trust; Heart and Stroke Foundation of Canada","keywords":"Polyphosphate; Mitochondrial permeability transition pore; Mitochondrion; Biophysics; Calcium; Mitochondrial membrane transport protein; Chemistry; Membrane; Permeability (electromagnetism); Cytoplasm; Ion transporter; Inner mitochondrial membrane; Biochemistry; Programmed cell death; Cell biology; Biology; Phosphate; Apoptosis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001523667,0.0001820739,0.0001320674,0.00006866112,0.00008620855,0.0001982451,0.0001351454,0.0002586372,0.0004066795],"category_scores_gemma":[0.0001677074,0.00008795215,0.0001218449,0.000055593,0.0002366504,0.0003716018,0.0001566948,0.0004195787,0.0000762847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001366385,"about_ca_system_score_gemma":0.00008531607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008217258,"about_ca_topic_score_gemma":0.0001061039,"domain_scores_codex":[0.9999167,0.00002550523,0.000009008882,0.00001477219,0.00001808489,0.00001587254],"domain_scores_gemma":[0.9998957,0.00003669518,0.00003049137,0.0000102441,0.000008528609,0.00001821459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006689892,0.000009898457,0.00004046472,0.00003392801,0.000001503279,0.00003727383,0.000006206525,0.00002216339,0.9993621,0.00008705159,0.000005628392,0.0003268536],"study_design_scores_gemma":[0.00001668083,0.0002255506,0.001210863,0.000004023378,0.000006371195,0.0002026536,0.00000816543,0.0003037037,0.9972199,0.00007008004,0.0007300653,0.000001859035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930768,0.002741219,0.003071187,0.0001419958,0.00002477722,0.00002375462,0.0000721927,0.00002129332,0.0008268566],"genre_scores_gemma":[0.9965946,0.0009926228,0.001928561,0.00003538219,0.000006987649,0.00002123601,0.00006446221,0.000004047648,0.0003520705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004066795,"threshold_uncertainty_score":0.001360476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005561096766959681,"score_gpt":0.2211662248949303,"score_spread":0.2156051281279707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}