{"id":"W2280120506","doi":"10.1136/jclinpath-2015-203066","title":"Evaluation of cell-line-derived xenograft tumours as controls for immunohistochemical testing for ER and PR","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Pathology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. John’s Health Sciences Centre; Memorial University of Newfoundland","funders":"","keywords":"Immunohistochemistry; Biomarker; Estrogen receptor; Medicine; Pathology; Breast tumours; Progesterone receptor; Oncology; Anatomical pathology; Breast cancer; Cancer research; Biology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005514504,0.0007059325,0.0005272972,0.0008898909,0.0005239297,0.0007317121,0.0005385869,0.0009404181,0.002887218],"category_scores_gemma":[0.003287839,0.0004436217,0.0004827848,0.000707221,0.0007987714,0.0003487954,0.0005719142,0.0009424494,0.000988798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005008603,"about_ca_system_score_gemma":0.0004976151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001812074,"about_ca_topic_score_gemma":0.003979342,"domain_scores_codex":[0.9960847,0.001320512,0.0004609755,0.0005554203,0.001291201,0.000287167],"domain_scores_gemma":[0.9930319,0.001635396,0.0005132378,0.002352528,0.002242503,0.0002244603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003632209,0.0002924608,0.003623399,0.0001172555,0.00003045609,0.0001704484,0.0002193167,0.000204769,0.9914383,0.0003664868,0.0003774378,0.002796413],"study_design_scores_gemma":[0.00008062446,0.001657561,0.02592686,0.00002303085,0.0001044861,0.001226904,0.0001416681,0.002906814,0.9586364,0.0001338396,0.009140373,0.00002145706],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7803136,0.002165142,0.1989607,0.0003197702,0.0005224512,0.004392601,0.002580298,0.001864119,0.008881319],"genre_scores_gemma":[0.7995507,0.001660996,0.1740835,0.0004286317,0.00005954847,0.005309783,0.008102903,0.0009117174,0.009892302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005514504,"threshold_uncertainty_score":0.02916384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4007843313420886,"score_gpt":0.5600717471712227,"score_spread":0.1592874158291341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}