{"id":"W2280120506","doi":"10.1136/jclinpath-2015-203066","title":"Evaluation of cell-line-derived xenograft tumours as controls for immunohistochemical testing for ER and PR","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Pathology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. John’s Health Sciences Centre; Memorial University of Newfoundland","funders":"","keywords":"Immunohistochemistry; Biomarker; Estrogen receptor; Medicine; Pathology; Breast tumours; Progesterone receptor; Oncology; Anatomical pathology; Breast cancer; Cancer research; Biology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01865575,0.0001096357,0.0009032956,0.0001057569,0.00002845147,0.000007492146,0.0001317827,0.0002504375,0.00001553174],"category_scores_gemma":[0.06919529,0.0000848829,0.0002506947,0.0000811211,0.00032478,0.00005028721,0.00004007181,0.0005006789,0.00000209773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009892154,"about_ca_system_score_gemma":0.001843248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003743061,"about_ca_topic_score_gemma":0.000001045111,"domain_scores_codex":[0.9967716,0.0004770083,0.001590715,0.000194812,0.0007108256,0.0002550692],"domain_scores_gemma":[0.989638,0.003971605,0.0009619633,0.0001873374,0.004918371,0.0003226721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01433618,0.00130337,0.04523505,0.0003891363,0.0002526521,0.0001389422,0.0004924009,0.0000800317,0.842853,0.00005582988,0.005653635,0.08920977],"study_design_scores_gemma":[0.3105653,0.1885678,0.1466367,0.002332104,0.01056618,0.0100052,0.00244023,0.04428312,0.2013293,0.06961901,0.01244117,0.001213802],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918002,0.001675111,0.002180738,0.00222786,0.0004755886,0.001050821,0.00001073073,0.000006125187,0.0005728626],"genre_scores_gemma":[0.9732694,0.000035789,0.02537751,0.0003298057,0.0008521064,0.00004932422,0.000004096808,0.00002377767,0.00005819023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6415237,"threshold_uncertainty_score":0.9386452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4007843313420886,"score_gpt":0.5600717471712227,"score_spread":0.1592874158291341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}