{"id":"W2280289181","doi":"10.1039/c5sc03856a","title":"Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone","year":2016,"lang":"en","type":"article","venue":"Chemical Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"Ferring Research Institute; Alberta Glycomics Centre; Royal Society of Chemistry; Royal Society","keywords":"Chemistry; Combinatorial chemistry; Nucleophile; Peptide; Nucleophilic aromatic substitution; Amino acid; Cyclic peptide; Reactivity (psychology); Aqueous solution; Stereochemistry; Nucleophilic substitution; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001848202,0.0004033858,0.0001427718,0.0001932996,0.0002064792,0.0002010795,0.0001568968,0.0002572751,0.001651612],"category_scores_gemma":[0.0001885805,0.0001248708,0.0001264511,0.0001317786,0.0001912941,0.0002266707,0.0001875179,0.0003283419,0.0005428779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001757955,"about_ca_system_score_gemma":0.0002741881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004607539,"about_ca_topic_score_gemma":0.001306362,"domain_scores_codex":[0.9998857,0.00001988702,0.000008582258,0.00003032472,0.00002364842,0.00003194168],"domain_scores_gemma":[0.9999114,0.00001780885,0.00002801582,0.00001063935,0.000008466997,0.00002360915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009116323,0.00001208006,0.00006603223,0.0000378017,0.000003036558,0.00007175171,0.00001622699,0.000102859,0.994144,0.0002677809,0.0001793679,0.005007807],"study_design_scores_gemma":[0.00001376478,0.0002192373,0.0006433768,0.000004234907,0.000004207917,0.0001767004,0.00000623686,0.0002515225,0.993687,0.00004510118,0.004942147,0.000006505973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9509006,0.008817885,0.02923051,0.0003667137,0.0003349792,0.0003004397,0.000767759,0.0004630124,0.008818213],"genre_scores_gemma":[0.9719436,0.002837773,0.01696067,0.0001710903,0.00004506081,0.0001318063,0.0006447249,0.00007629832,0.007188964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001651612,"threshold_uncertainty_score":0.005525231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006750143431886737,"score_gpt":0.2188010880875681,"score_spread":0.2120509446556813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}