{"id":"W2280289181","doi":"10.1039/c5sc03856a","title":"Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone","year":2016,"lang":"en","type":"article","venue":"Chemical Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"Ferring Research Institute; Alberta Glycomics Centre; Royal Society of Chemistry; Royal Society","keywords":"Chemistry; Combinatorial chemistry; Nucleophile; Peptide; Nucleophilic aromatic substitution; Amino acid; Cyclic peptide; Reactivity (psychology); Aqueous solution; Stereochemistry; Nucleophilic substitution; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001369892,0.00008876486,0.0001201194,0.00002809972,0.00004346913,0.00001186773,0.0002921336,0.0000475655,0.00006411484],"category_scores_gemma":[0.0001625762,0.00004970602,0.00005244834,0.0003269533,0.0006640821,0.000008212061,0.00009927665,0.0000193523,0.000005325694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000167809,"about_ca_system_score_gemma":0.00004859351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007445483,"about_ca_topic_score_gemma":0.000001776696,"domain_scores_codex":[0.9990876,0.000007147481,0.0001502282,0.0003285754,0.0002223449,0.0002040582],"domain_scores_gemma":[0.9994431,0.00001994665,0.00007560715,0.0002426939,0.0001141489,0.0001045324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000242887,0.00003747388,0.002559176,0.000005238603,0.000007670121,1.551724e-7,0.000004722575,7.918993e-7,0.9813389,0.00004796695,0.0001049529,0.01586868],"study_design_scores_gemma":[0.000200317,0.00004425072,0.0005806793,0.00003533853,0.00001014017,0.000002273288,0.000007964524,0.00001836123,0.9972553,0.00006652092,0.001675267,0.0001035362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957827,0.0001384999,0.002724089,0.0001416198,0.000008378363,0.00004253157,0.00000540431,0.00000774859,0.00114901],"genre_scores_gemma":[0.9975558,0.00008556886,0.002165203,0.00003923341,0.00004790491,0.000005259033,0.000005438164,0.000006100036,0.00008952762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01591647,"threshold_uncertainty_score":0.2446838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006750143431886737,"score_gpt":0.2188010880875681,"score_spread":0.2120509446556813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}