{"id":"W2280426197","doi":"10.1093/cercor/bhv335","title":"Adolescent Cannabinoid Exposure Induces a Persistent Sub-Cortical Hyper-Dopaminergic State and Associated Molecular Adaptations in the Prefrontal Cortex","year":2016,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Prefrontal cortex; Endophenotype; Neuroscience; Dopaminergic; Dopamine; Psychology; Schizophrenia (object-oriented programming); Psychosis; Cannabinoid; Medicine; Internal medicine; Psychiatry; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000627893,0.0002333747,0.0002107355,0.0004089343,0.0001655666,0.0002171505,0.0001150952,0.0001711805,0.0008758164],"category_scores_gemma":[0.0001257801,0.0001429988,0.0001552702,0.0001284512,0.0003333233,0.000129956,0.0001718487,0.0004489111,0.00008909979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003346466,"about_ca_system_score_gemma":0.0003450846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003339038,"about_ca_topic_score_gemma":0.009098561,"domain_scores_codex":[0.9999064,0.000009685588,0.000005405983,0.00002796034,0.00002803128,0.00002249402],"domain_scores_gemma":[0.9998292,0.00001929655,0.0000717297,0.00001592545,0.00002177035,0.00004196744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004783519,0.0001001985,0.00579797,0.00003407599,0.00002484499,0.0002824806,0.00009514742,0.00003886823,0.9904247,0.00009192395,0.00003379936,0.002597611],"study_design_scores_gemma":[0.00003547625,0.001737752,0.330754,0.00003008477,0.00008967839,0.00149544,0.0006877845,0.0005093589,0.6635529,0.0002382607,0.0008534641,0.00001587183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990076,0.0002618851,0.0003430943,0.0000240349,0.000004506718,0.000006127873,0.00009660151,0.00001080581,0.0002453],"genre_scores_gemma":[0.9981555,0.0004436366,0.0004910451,0.00002805111,0.000002508953,0.00001782263,0.0001260732,0.00000506519,0.0007303914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003339038,"threshold_uncertainty_score":0.006639242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807062291484162,"score_gpt":0.2574712433312819,"score_spread":0.2394006204164403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}