{"id":"W2280430690","doi":"10.1080/15265161.2015.1039732","title":"The Role of Whole Genome and Whole Exome Sequencing in Preventive Genomic Sequencing Programs","year":2015,"lang":"en","type":"letter","venue":"The American Journal of Bioethics","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Aalborg Universitet","keywords":"Exome sequencing; Genomic sequencing; Exome; Whole genome sequencing; Computational biology; Genome; Genetics; Biology; DNA sequencing; Genomics; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01079261,0.0005117627,0.0009046721,0.0007907592,0.00141668,0.002851676,0.001663878,0.01364485,0.01186643],"category_scores_gemma":[0.04588222,0.0006859341,0.0006824069,0.0004554392,0.002135245,0.003583699,0.001687554,0.02031074,0.005749028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002230458,"about_ca_system_score_gemma":0.001720324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001523876,"about_ca_topic_score_gemma":0.003967661,"domain_scores_codex":[0.9929723,0.00295596,0.0009243304,0.0004792796,0.002174684,0.0004934259],"domain_scores_gemma":[0.9329512,0.04996639,0.002342422,0.002505581,0.007173487,0.005060915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002702456,0.000116167,0.003732295,0.0002330963,0.00004045272,0.005696913,0.00036771,0.0003227413,0.003041693,0.01395047,0.8233206,0.1489076],"study_design_scores_gemma":[0.0001713692,0.0003322618,0.00539482,0.0007039484,0.00007384851,0.01360437,0.0003640927,0.004748819,0.003992116,0.02951632,0.9409839,0.0001140875],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003094095,0.003967263,0.01038864,0.9454597,0.0195582,0.00008056183,0.0000852784,0.0006818458,0.01668446],"genre_scores_gemma":[0.06411062,0.006874613,0.03875892,0.7929251,0.07356511,0.0003106799,0.0001811067,0.0004494801,0.02282442],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01364485,"threshold_uncertainty_score":0.05707747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02650533395621387,"score_gpt":0.2746567289145291,"score_spread":0.2481513949583152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}