{"id":"W2280682835","doi":"10.1002/jcph.714","title":"Effect of Renal and Hepatic Impairment on the Pharmacokinetics of Cabozantinib","year":2016,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada)","funders":"Exelixis","keywords":"Cabozantinib; Pharmacokinetics; Medicine; Tyrosine-kinase inhibitor; Internal medicine; Adverse effect; Renal function; Gastroenterology; Dosing; Body mass index; Toxicity; Urology; Oncology; Cancer; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009930084,0.0001130564,0.0009667566,0.00007380556,0.00003938029,0.00000112183,0.0002383614,0.00009425452,0.000647497],"category_scores_gemma":[0.001764336,0.00003814513,0.0002011311,0.00009248527,0.001076906,0.0000207525,0.00007935729,0.0005280168,0.000007907399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001722089,"about_ca_system_score_gemma":0.0002281564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000467609,"about_ca_topic_score_gemma":4.168654e-7,"domain_scores_codex":[0.995713,0.002391856,0.00124235,0.00008597371,0.0003632519,0.0002035928],"domain_scores_gemma":[0.9765437,0.02203824,0.0008618043,0.0001632524,0.0002350916,0.0001579544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.07841066,0.002113791,0.4254188,0.0004372978,0.003611556,0.0001880595,0.0004284308,0.00001201844,0.3797252,0.000188001,0.04746002,0.06200612],"study_design_scores_gemma":[0.06747324,0.1244879,0.3588669,0.001177567,0.01086404,0.001163877,0.00009883956,0.001291339,0.4234549,0.0006997877,0.01019046,0.0002311443],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847115,0.0003518144,0.00007575444,0.013383,0.0004135157,0.0004307793,0.000004670656,0.000002451406,0.0006265152],"genre_scores_gemma":[0.9939449,0.004253501,0.00004730242,0.0009900719,0.0005326113,0.000003866389,1.228391e-7,0.000009037817,0.0002186031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1223741,"threshold_uncertainty_score":0.7089638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06468027082223873,"score_gpt":0.4890645115591757,"score_spread":0.4243842407369369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}