{"id":"W2280704272","doi":"10.1139/cjm-2015-0595","title":"Vcx1-D1 (M383I), the Vcx1 mutant with a calcineurin-independent vacuolar Ca<sup>2+</sup>/H<sup>+</sup> exchanger activity, confers calcineurin-independent Mn<sup>2+</sup> tolerance in <i>Saccharomyces cerevisiae</i>","year":2016,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Jiangnan University; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Calcineurin; Mutant; Endoplasmic reticulum; Saccharomyces cerevisiae; Biology; Vacuole; Yeast; Biochemistry; Cell biology; Molecular biology; Chemistry; Cytoplasm; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007426813,0.0008333169,0.0003561995,0.0002911804,0.0002429552,0.0004041017,0.0005790703,0.0003608168,0.001653327],"category_scores_gemma":[0.00009958016,0.0001769661,0.0002960771,0.0003332324,0.0003012533,0.0001678626,0.0003542212,0.000499565,0.0007393658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006797852,"about_ca_system_score_gemma":0.0002582712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002318494,"about_ca_topic_score_gemma":0.002027203,"domain_scores_codex":[0.9998984,0.000007890915,0.00001279011,0.0000333825,0.00002918825,0.0000183526],"domain_scores_gemma":[0.9998864,0.0000162823,0.00003996066,0.00001584517,0.000009554169,0.00003202088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004931563,0.00001404352,0.0002196102,0.00003418888,0.000005028942,0.00006937297,0.00001050163,0.0001038966,0.9983605,0.0001158838,0.00005226592,0.0009654892],"study_design_scores_gemma":[0.00001365389,0.00007827669,0.004601075,0.000007173335,0.00001173309,0.0006338563,0.0000262733,0.001086416,0.9893612,0.00004769323,0.004124542,0.000008059592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906019,0.001415729,0.003350496,0.0000883754,0.00005639812,0.00004178374,0.002255227,0.0002096118,0.001980427],"genre_scores_gemma":[0.9825382,0.0008575158,0.003704082,0.0000458703,0.000007315901,0.00004063357,0.00448341,0.0001196647,0.008203457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002318494,"threshold_uncertainty_score":0.005530894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233209830050865,"score_gpt":0.233449454744219,"score_spread":0.2211173564437103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}