{"id":"W2280904264","doi":"10.1016/s0022-3549(15)00188-4","title":"Comparison of Linear and Cyclic His-Ala-Val Peptides in Modulating the Blood-Brain Barrier Permeability: Impact on Delivery of Molecules to the Brain","year":2016,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health","keywords":"In vivo; Blood–brain barrier; Chemistry; Peptide; Cyclic peptide; In vitro; Biophysics; Extracellular; Intracellular; Receptor; Tight junction; Ex vivo; Biochemistry; Biology; Central nervous system; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003159928,0.0002460254,0.0002580039,0.0001486549,0.0001050035,0.0002882871,0.0002758929,0.000341211,0.001632298],"category_scores_gemma":[0.0003821824,0.0001469973,0.0001928879,0.0001468562,0.0002576431,0.0004360972,0.0001359351,0.0004451484,0.0001446155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001728466,"about_ca_system_score_gemma":0.0002289404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004832307,"about_ca_topic_score_gemma":0.0005410647,"domain_scores_codex":[0.9998828,0.00002410802,0.00001391069,0.00002013471,0.00001849831,0.00004055003],"domain_scores_gemma":[0.9998035,0.00007375167,0.00003494977,0.00001222895,0.000023123,0.00005251723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004047886,0.0002065992,0.0001270369,0.0001470794,0.00002376837,0.00006976692,0.00002717834,0.0005957995,0.989606,0.0001293172,0.0000655993,0.004954045],"study_design_scores_gemma":[0.000267319,0.006646797,0.001071147,0.00001056288,0.00007782209,0.000133368,0.00003179271,0.001038983,0.989324,0.00005480254,0.001330575,0.00001277557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974191,0.001531882,0.0004415046,0.00004010077,0.00002942578,0.0000215795,0.00008556374,0.000009117307,0.0004217543],"genre_scores_gemma":[0.9962732,0.001412524,0.001352499,0.00004139931,0.00001728709,0.00002744277,0.0001396535,0.000008442435,0.0007274965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001632298,"threshold_uncertainty_score":0.00546062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0447182815598909,"score_gpt":0.3939811913837635,"score_spread":0.3492629098238726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}