{"id":"W2280940680","doi":"10.1186/s40478-016-0277-8","title":"CSF complement 3 and factor H are staging biomarkers in Alzheimer’s disease","year":2016,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; University of California, San Diego; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Genentech; National Institutes of Health; National Institute of Neurological Disorders and Stroke; IXICO; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Association; Amorfix Life Sciences; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; F. Hoffmann-La Roche; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Novartis Pharmaceuticals Corporation; Medpace; Emory University; Synarc; University of Southern California; Foundation for the National Institutes of Health; American Federation for Aging Research","keywords":"Neurology; Disease; Factor H; Medicine; Alzheimer's disease; Complement (music); Pathology; Complement system; Psychiatry; Immunology; Biology; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002518563,0.001163038,0.0006783255,0.0006857286,0.0003327778,0.001198948,0.0005820761,0.0004432951,0.001009493],"category_scores_gemma":[0.004414036,0.0003471955,0.0006971289,0.0005745821,0.0004152299,0.000483386,0.000537079,0.0007589528,0.0003263026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001083573,"about_ca_system_score_gemma":0.001516961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02763965,"about_ca_topic_score_gemma":0.02215527,"domain_scores_codex":[0.9996201,0.0001323688,0.00002252574,0.0001234959,0.00006261561,0.0000389011],"domain_scores_gemma":[0.9990987,0.0004345216,0.0001768402,0.00007297504,0.0001547226,0.00006225638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002920183,0.000283638,0.7879156,0.0002162264,0.0008644378,0.000222814,0.0002119134,0.07349981,0.01321973,0.000559662,0.002874657,0.1172114],"study_design_scores_gemma":[0.0001179279,0.0006292853,0.3468674,0.0001046818,0.0004895372,0.0003443462,0.0001123357,0.6374843,0.0083847,0.003609783,0.001791271,0.00006432228],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748194,0.002000624,0.02025116,0.0005979917,0.00003117724,0.00008806472,0.0009669135,0.0003222272,0.0009224282],"genre_scores_gemma":[0.985984,0.0003700814,0.01251859,0.00006470398,0.00001709864,0.00003189146,0.0006490793,0.00001691802,0.0003477226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02763965,"threshold_uncertainty_score":0.05495757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09219119106796984,"score_gpt":0.3121819425075198,"score_spread":0.2199907514395499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}