{"id":"W2281029936","doi":"10.3899/jrheum.150523","title":"GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness","year":2016,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Foundation of Korea; Ministry of Education, Science and Technology; Catholic University of Korea; National Research Foundation","keywords":"Gene knockdown; Western blot; Cancer research; Proinflammatory cytokine; Small interfering RNA; Downregulation and upregulation; Integrin; Medicine; Transfection; Apoptosis; Biology; Molecular biology; Immunology; Cell culture; Inflammation; Receptor; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001574717,0.000497543,0.0004114617,0.0004067152,0.0001899647,0.0003675787,0.0002141134,0.0002896918,0.001197942],"category_scores_gemma":[0.0001674561,0.0001256058,0.0004543949,0.0003229617,0.0001502314,0.000180785,0.0002101787,0.0002475143,0.0004648677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002455026,"about_ca_system_score_gemma":0.0001928778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000384745,"about_ca_topic_score_gemma":0.0005461851,"domain_scores_codex":[0.9998473,0.00001535475,0.000008365,0.00004159914,0.00006012115,0.00002733062],"domain_scores_gemma":[0.9998962,0.00001212542,0.00005504588,0.000006438656,0.00001599135,0.00001416982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002716206,0.00002815467,0.00846904,0.0003271815,0.0000374683,0.0001805411,0.00003230943,0.001052695,0.9795043,0.0002523582,0.0002620219,0.009582248],"study_design_scores_gemma":[0.00007379904,0.0008671016,0.1991779,0.000103972,0.0002801532,0.002480066,0.000276482,0.03513439,0.737859,0.0008832533,0.02281219,0.000051624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750196,0.009881101,0.01027424,0.000156547,0.00003721418,0.00004733912,0.002404016,0.0003437516,0.001836246],"genre_scores_gemma":[0.9865284,0.002435409,0.006192089,0.00007878224,0.00002008138,0.00004833701,0.002649379,0.00003029027,0.002017282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001197942,"threshold_uncertainty_score":0.004007518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337747630413044,"score_gpt":0.2574775028200978,"score_spread":0.2441000265159673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}