{"id":"W2281054724","doi":"10.1016/j.mce.2016.02.019","title":"Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP","year":2016,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Docosahexaenoic acid; Gonadotropin-releasing hormone; Internal medicine; Endocrinology; Biology; Wortmannin; Messenger RNA; GPR120; Chemistry; Polyunsaturated fatty acid; Fatty acid; Cell biology; Phosphatidylinositol; Biochemistry; Hormone; Signal transduction; G protein-coupled receptor; Luteinizing hormone; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004115466,0.0004766052,0.0007893145,0.0002107033,0.0001786554,0.0000343345,0.0002765236,0.0002259446,0.00002356341],"category_scores_gemma":[0.0002763599,0.0002545279,0.0001608034,0.0002698225,0.0009484749,0.0001653578,0.0002396643,0.0006499809,0.000006953786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006014299,"about_ca_system_score_gemma":0.00008800493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006641234,"about_ca_topic_score_gemma":0.000009405336,"domain_scores_codex":[0.9966198,0.000761547,0.0006329352,0.000893448,0.000377672,0.000714612],"domain_scores_gemma":[0.998435,0.0001838544,0.0003169765,0.0007713031,0.0001611896,0.0001316778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00163234,0.00011441,0.0008350447,0.00004527782,0.0001027402,0.0001389165,0.0003442543,0.000012302,0.9826692,0.0002467223,0.00005444888,0.01380434],"study_design_scores_gemma":[0.007044933,0.0002674829,0.002490703,0.00008114751,0.0002078564,0.0004082503,0.0002282105,0.0006730995,0.9872738,0.0006851368,0.0003641208,0.00027533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965117,0.01717377,0.008483793,0.00773908,0.0001494098,0.001016221,0.0000238728,0.00006062979,0.0002362096],"genre_scores_gemma":[0.9979891,0.0008671157,0.000444973,0.0003307147,0.00006323699,0.0000949793,0.00002638814,0.00005872515,0.000124777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03287207,"threshold_uncertainty_score":0.9999907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186396090269749,"score_gpt":0.2174214173809668,"score_spread":0.2055574564782693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}