{"id":"W2281054724","doi":"10.1016/j.mce.2016.02.019","title":"Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP","year":2016,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Docosahexaenoic acid; Gonadotropin-releasing hormone; Internal medicine; Endocrinology; Biology; Wortmannin; Messenger RNA; GPR120; Chemistry; Polyunsaturated fatty acid; Fatty acid; Cell biology; Phosphatidylinositol; Biochemistry; Hormone; Signal transduction; G protein-coupled receptor; Luteinizing hormone; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003254678,0.000349188,0.0004016918,0.0004043543,0.0004378481,0.00045672,0.0005111129,0.0005197773,0.001530556],"category_scores_gemma":[0.0001581683,0.0002920305,0.0004865278,0.0003369862,0.0008108527,0.000548215,0.0003438913,0.001572229,0.0004144963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007611227,"about_ca_system_score_gemma":0.000579097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00266869,"about_ca_topic_score_gemma":0.004654432,"domain_scores_codex":[0.9996723,0.00002919317,0.00003637475,0.0001016056,0.00007308437,0.00008751944],"domain_scores_gemma":[0.9997084,0.00004898124,0.00006410739,0.00003806446,0.00002851919,0.0001120103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003422604,0.00003954657,0.00009495246,0.00001652217,0.000003682286,0.00004292363,0.00003359265,0.00003658988,0.9988538,0.0001999746,0.00003250484,0.0003035959],"study_design_scores_gemma":[0.00006804446,0.0003478392,0.001246266,0.000004467534,0.00001486141,0.00009311243,0.0001169646,0.0007266987,0.9959819,0.00007133604,0.001322737,0.000005868186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926537,0.000433419,0.003510219,0.0003225126,0.000203431,0.00006516602,0.001138694,0.00007959243,0.001593285],"genre_scores_gemma":[0.9804571,0.0006201899,0.008128138,0.000148667,0.00003422132,0.0001433353,0.001380365,0.0001356828,0.008952232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00266869,"threshold_uncertainty_score":0.00552237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186396090269749,"score_gpt":0.2174214173809668,"score_spread":0.2055574564782693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}