{"id":"W2281286478","doi":"10.2337/db15-1033","title":"miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy","year":2015,"lang":"en","type":"article","venue":"Diabetes","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Diabetes Association","keywords":"Diabetic cardiomyopathy; Cardiac fibrosis; Endocrinology; Mesenchymal stem cell; Internal medicine; Endothelium; Endothelial dysfunction; Diabetes mellitus; microRNA; Genetically modified mouse; Autophagy; Medicine; In vivo; Downregulation and upregulation; Fibrosis; Biology; Transgene; Cardiomyopathy; Heart failure; Cell biology; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107902,0.0002982884,0.0001916379,0.0001845724,0.0001825065,0.0002478853,0.0001652903,0.0002479789,0.001152173],"category_scores_gemma":[0.00008979691,0.0001659071,0.0001373837,0.00008783631,0.0001613357,0.0001180294,0.0002018413,0.0004394197,0.0005684242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002129917,"about_ca_system_score_gemma":0.0001313072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002912953,"about_ca_topic_score_gemma":0.0003429034,"domain_scores_codex":[0.9999275,0.00001303779,0.000005120186,0.00001582163,0.00001796036,0.00002053177],"domain_scores_gemma":[0.9999447,0.000004763009,0.00001840598,0.000003368921,0.000004986984,0.00002378399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002404119,0.00005312306,0.0003746022,0.00005638614,0.000004888839,0.0001903915,0.00001432588,0.00005082514,0.9971335,0.0003007856,0.0001457648,0.001434949],"study_design_scores_gemma":[0.0001675633,0.0006932102,0.04390061,0.00004393669,0.00005886661,0.001733892,0.0001187027,0.004999056,0.9327977,0.0006095321,0.01485838,0.00001863415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803934,0.007938365,0.005883709,0.0002616627,0.0001276238,0.00004512482,0.0003857565,0.0001881898,0.004776044],"genre_scores_gemma":[0.9944515,0.001761258,0.0009510402,0.0001023719,0.00001618321,0.00004332768,0.0003158883,0.00001704905,0.002341317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152173,"threshold_uncertainty_score":0.003854454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009087846867566309,"score_gpt":0.2255432080447963,"score_spread":0.21645536117723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}