{"id":"W2281286478","doi":"10.2337/db15-1033","title":"miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy","year":2015,"lang":"en","type":"article","venue":"Diabetes","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Diabetes Association","keywords":"Diabetic cardiomyopathy; Cardiac fibrosis; Endocrinology; Mesenchymal stem cell; Internal medicine; Endothelium; Endothelial dysfunction; Diabetes mellitus; microRNA; Genetically modified mouse; Autophagy; Medicine; In vivo; Downregulation and upregulation; Fibrosis; Biology; Transgene; Cardiomyopathy; Heart failure; Cell biology; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002419597,0.0001440014,0.0001608529,0.00009706298,0.0000206184,0.00002094412,0.0001233476,0.0001104552,0.00001229539],"category_scores_gemma":[0.0001459742,0.000148967,0.00007308398,0.000147357,0.00004149139,0.000006314352,0.00004060927,0.00004837746,0.00005844355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003350865,"about_ca_system_score_gemma":0.00007070314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001284813,"about_ca_topic_score_gemma":0.00001084993,"domain_scores_codex":[0.998974,0.00009036829,0.0001824812,0.0002982676,0.0001540293,0.0003008161],"domain_scores_gemma":[0.9994425,0.00001303622,0.00003456823,0.000250868,0.00007303338,0.0001860056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002486812,0.0000505489,0.02397132,0.00001989139,0.00002119834,0.000002741647,0.0002369308,0.0006003838,0.9729129,0.000009574723,0.001281704,0.0008679065],"study_design_scores_gemma":[0.0009916753,0.0001862043,0.03695189,0.00003316417,0.00002483356,0.000001195669,0.0001029211,0.0003264459,0.9542241,0.0002994993,0.006553248,0.0003048864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976491,0.00111557,0.0001110302,0.00024336,0.0001842771,0.0002556721,0.00006599911,0.0000192974,0.000355732],"genre_scores_gemma":[0.9987194,0.000009800149,0.000309307,0.0002727091,0.0002892695,0.00007221353,0.0002652257,0.00002486392,0.00003722289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0186889,"threshold_uncertainty_score":0.6074699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009087846867566309,"score_gpt":0.2255432080447963,"score_spread":0.21645536117723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}