{"id":"W2281288520","doi":"10.1016/j.neurobiolaging.2016.02.015","title":"The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable","year":2016,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Janssen Research and Development; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; University of California, Irvine; University of California, Davis; GE Healthcare; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; Johnson and Johnson; Genentech; Fujirebio Europe; North Bristol NHS Trust; National Cancer Institute; Lundbeckfonden; Canadian Institutes of Health Research; Stichting MS Research; Alzheimer's Research Trust; F. Hoffmann-La Roche; Rush University; U.S. Department of Defense; BRACE; University of Alabama at Birmingham; National Center for Advancing Translational Sciences; Novartis Pharmaceuticals Corporation; Takeda Pharmaceutical Company; Roche; University of Pittsburgh; Higher Education Funding Council for England; National Association for Colitis and Crohn's Disease; University of Arizona; McDonnell Center for Systems Neuroscience; University of California, San Diego; Johns Hopkins University; University of California, Los Angeles; Pfizer; University of Washington; Medical Research Council; Servier; Boston University; Meso Scale Diagnostics; Emory University; U.S. Department of Veterans Affairs; University of Pennsylvania; Columbia University; Massachusetts General Hospital; Translational Genomics Research Institute; Indiana University; Vanderbilt University; Wellcome Trust; Eisai; University of Southern California; Duke University; AbbVie; Wellcome; Oregon Health and Science University; University of Michigan; University of California, San Francisco; GlaxoSmithKline; Mayo Clinic; Merck; National Institutes of Health; Alzheimer's Drug Discovery Foundation; BioClinica; Newcastle University; Icahn School of Medicine at Mount Sinai; Alzheimer's Disease Neuroimaging Initiative; Northwestern University; Biogen; University of Miami; Hersenstichting; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; University of Kentucky; New York University; Howard Hughes Medical Institute; University of Texas Southwestern Medical Center","keywords":"Heritability; Neuropsychology; Executive functions; Dementia; Executive dysfunction; Psychology; Dysexecutive syndrome; Early-onset Alzheimer's disease; Disease; Neuroscience; Audiology; Genetics; Cognition; Biology; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006174328,0.001487995,0.0007057106,0.003364967,0.001042223,0.001136662,0.000688486,0.0006770016,0.006330199],"category_scores_gemma":[0.003072735,0.0004698797,0.00044696,0.001859496,0.0009422578,0.001142684,0.001227614,0.0008439851,0.0007551958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002944357,"about_ca_system_score_gemma":0.0004928694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004201705,"about_ca_topic_score_gemma":0.004962163,"domain_scores_codex":[0.9995027,0.00007148737,0.00007717548,0.0001409387,0.0001302144,0.00007741757],"domain_scores_gemma":[0.998319,0.0002677864,0.0008062031,0.0001477822,0.0002685731,0.0001907187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001571811,0.0004311347,0.9271987,0.0001124014,0.0003036027,0.01864161,0.0007906343,0.0002200183,0.02040583,0.001193704,0.001199664,0.02793083],"study_design_scores_gemma":[0.00001596522,0.0001415423,0.985704,0.00002398204,0.000106947,0.01117713,0.0003752623,0.0001219301,0.0008724839,0.001066574,0.0003781026,0.0000159835],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941889,0.0006668671,0.0007477397,0.000231231,0.00003932968,0.00003136282,0.0005844475,0.0000608567,0.003449129],"genre_scores_gemma":[0.9975369,0.000410968,0.000612044,0.00007349056,0.00007868162,0.00001331957,0.0004178624,0.00002643118,0.0008302352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006330199,"threshold_uncertainty_score":0.02117658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666046278403995,"score_gpt":0.2834327345262088,"score_spread":0.2667722717421689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}