{"id":"W2281374119","doi":"10.1016/j.yjmcc.2016.01.014","title":"A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias","year":2016,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Nav1.5; Sodium channel; Gating; Membrane potential; Mutation; Mutant; Internal medicine; Lidocaine; Biophysics; Chemistry; Patch clamp; Voltage clamp; Sodium channel blocker; NAV1; Electrophysiology; Medicine; Biology; Sodium; Anesthesia; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003727153,0.0001738778,0.0006819644,0.0001235804,0.00006172181,0.000008533056,0.00003131391,0.0002184448,0.000007151928],"category_scores_gemma":[0.0002795516,0.00010427,0.0003263153,0.0001046597,0.0001682426,0.00005719982,0.00002574785,0.000254849,0.000001874232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004927826,"about_ca_system_score_gemma":0.0001035368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002063166,"about_ca_topic_score_gemma":4.215145e-7,"domain_scores_codex":[0.9988711,0.0001656485,0.0003050644,0.0002121456,0.0001947835,0.0002511982],"domain_scores_gemma":[0.9990954,0.0001402964,0.0002577809,0.0001305921,0.0002221711,0.0001537189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.001784364,0.00002843143,0.003031855,0.00002703013,0.002038623,0.04560006,0.00006192427,0.0001772677,0.9426732,0.0001755409,0.00008602642,0.004315702],"study_design_scores_gemma":[0.05629579,0.01372548,0.06023672,0.001063773,0.007623821,0.6772555,0.00042799,0.0001330574,0.1754778,0.001670388,0.004711404,0.001378243],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712541,0.003356979,0.02440486,0.0005454503,0.0001509923,0.0001611947,0.000009088035,0.00001040884,0.0001069466],"genre_scores_gemma":[0.9988056,0.0002002997,0.0002617176,0.0001641084,0.0004506365,0.00000164148,0.000008719493,0.00002026244,0.00008702531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7671953,"threshold_uncertainty_score":0.4252006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006056033544192633,"score_gpt":0.2089197336003382,"score_spread":0.2028637000561455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}