{"id":"W2281522039","doi":"10.1074/jbc.m115.681544","title":"Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) Are Proximal and Essential for Phosphatidylinositol 3-Kinase (PI3K) Activation in Natural Killer (NK) Cell-mediated Direct Cytotoxicity against Cryptococcus neoformans","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Kinase; Cell biology; Cryptococcus neoformans; Biology; Phosphatidylinositol; Src family kinase; Natural killer cell; PI3K/AKT/mTOR pathway; Chemistry; Signal transduction; Cancer research; Proto-oncogene tyrosine-protein kinase Src; Microbiology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000277603,0.0002427953,0.0005416297,0.00006108279,0.000130964,0.00002742948,0.00006329784,0.0002917139,0.00002686696],"category_scores_gemma":[0.0006009122,0.0001359536,0.0001371118,0.0001459914,0.000203616,0.0001544804,0.00004861986,0.0003774837,7.868264e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001041546,"about_ca_system_score_gemma":0.00006002875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006780686,"about_ca_topic_score_gemma":0.000002754068,"domain_scores_codex":[0.9986473,0.00003815578,0.0005981611,0.0002600603,0.0001522566,0.0003040207],"domain_scores_gemma":[0.998715,0.0003676117,0.0004327905,0.00008924933,0.0002370396,0.0001583313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001249551,0.0003149374,0.05866388,0.0001566888,0.00007745574,0.00005587479,0.00005135265,0.00000316521,0.9383968,0.000001631511,0.0003357818,0.0006928425],"study_design_scores_gemma":[0.004737795,0.0005505909,0.2124878,0.0004811497,0.00005020023,0.00004992651,0.0003034382,0.0001512699,0.7807318,0.00004091548,0.0002021504,0.0002130081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973525,0.001157238,0.00003391145,0.0005198994,0.0001527242,0.0003909363,0.00002500231,0.00002618445,0.0003416472],"genre_scores_gemma":[0.9981819,0.001153798,0.0001437219,0.0001165032,0.0002134591,0.00002534376,0.00002012659,0.00001116796,0.0001340225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1576651,"threshold_uncertainty_score":0.5544025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410727173880142,"score_gpt":0.2475877780580336,"score_spread":0.2334805063192322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}