{"id":"W2281522039","doi":"10.1074/jbc.m115.681544","title":"Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) Are Proximal and Essential for Phosphatidylinositol 3-Kinase (PI3K) Activation in Natural Killer (NK) Cell-mediated Direct Cytotoxicity against Cryptococcus neoformans","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Kinase; Cell biology; Cryptococcus neoformans; Biology; Phosphatidylinositol; Src family kinase; Natural killer cell; PI3K/AKT/mTOR pathway; Chemistry; Signal transduction; Cancer research; Proto-oncogene tyrosine-protein kinase Src; Microbiology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001585521,0.000369879,0.0002014547,0.0002352289,0.0002467727,0.0002128307,0.0001151619,0.0002406819,0.001741081],"category_scores_gemma":[0.0001024554,0.0001157318,0.0003626884,0.0001115021,0.000183293,0.0001742764,0.0002326087,0.0004116875,0.000396401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004798117,"about_ca_system_score_gemma":0.0003782571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270415,"about_ca_topic_score_gemma":0.001951849,"domain_scores_codex":[0.9998337,0.00002204283,0.00001271393,0.00002798117,0.00004328414,0.00006017896],"domain_scores_gemma":[0.9999321,0.00001015118,0.00001908098,0.000009662043,0.00001114757,0.00001790139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001431989,0.00002350548,0.0007618084,0.00004316946,0.000004287653,0.0001090356,0.00001271811,0.0000487352,0.9968034,0.0001071792,0.00002587251,0.001917084],"study_design_scores_gemma":[0.00001939986,0.0002958923,0.02677509,0.00001113643,0.00002722945,0.001908408,0.00004982594,0.001376972,0.9663205,0.0001024329,0.003107115,0.000006167637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951126,0.001265731,0.00163475,0.00007132797,0.00001515573,0.0000302321,0.0002427607,0.00004098283,0.001586572],"genre_scores_gemma":[0.9961156,0.0005124118,0.00146595,0.00002642528,0.000003720211,0.00001635345,0.0002678832,0.000004240381,0.001587467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001741081,"threshold_uncertainty_score":0.005824506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410727173880142,"score_gpt":0.2475877780580336,"score_spread":0.2334805063192322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}