{"id":"W2281646699","doi":"10.1093/annonc/mdu344.2","title":"Phase Ib/Ii Study of Lee011 (Cdk4/6 Inhibitor) and Lgx818 (Braf Inhibitor) in Braf-Mutant Melanoma","year":2014,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Cancer research; Melanoma; Mutant; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001122404,0.001269136,0.001911364,0.000502535,0.0004344661,0.0009958096,0.001012339,0.001239953,0.004809768],"category_scores_gemma":[0.0005495614,0.0007264712,0.001375771,0.0004459652,0.0009129137,0.0009265958,0.0002961679,0.002972151,0.001255908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009183769,"about_ca_system_score_gemma":0.001590915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001984744,"about_ca_topic_score_gemma":0.007237755,"domain_scores_codex":[0.9997476,0.00009137158,0.00001293638,0.00004127184,0.00002032722,0.00008642708],"domain_scores_gemma":[0.9996427,0.00005087224,0.00003955909,0.00002731513,0.00001865395,0.0002208604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6737847,0.08732927,0.005345665,0.001202147,0.001769972,0.0003447866,0.0003514962,0.004209738,0.05394784,0.0007329486,0.007980908,0.1630004],"study_design_scores_gemma":[0.6214093,0.3597585,0.007494982,0.00005765568,0.0006059457,0.0003388499,0.0001373447,0.001455638,0.00442057,0.0003617305,0.003912961,0.00004650958],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878708,0.003629294,0.0009229932,0.000687004,0.0002374515,0.002053977,0.001003832,0.000168855,0.003425905],"genre_scores_gemma":[0.9773982,0.004892162,0.002232544,0.001209523,0.0001902538,0.002199297,0.002935346,0.00005358959,0.008888988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004809768,"threshold_uncertainty_score":0.01609027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08539922642463935,"score_gpt":0.4215295563900914,"score_spread":0.3361303299654521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}