{"id":"W2281650010","doi":"10.1074/jbc.m115.712455","title":"Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia","keywords":"Islet; Innate immune system; Amyloid (mycology); Immune system; Cell biology; Differential (mechanical device); Biology; Immunology; Chemistry; Neuroscience; Diabetes mellitus; Endocrinology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001565476,0.0001918668,0.0004209291,0.00003221352,0.00006481627,0.000008935252,0.0002442653,0.0003107297,0.003594433],"category_scores_gemma":[0.0006168855,0.0001030313,0.0002207522,0.00006820303,0.0003317077,0.00008553715,0.00007652409,0.0002923517,0.0000271029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005720356,"about_ca_system_score_gemma":0.00004127705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005697908,"about_ca_topic_score_gemma":1.376103e-7,"domain_scores_codex":[0.9986605,0.0001119577,0.0007573062,0.0001755599,0.00006683752,0.000227844],"domain_scores_gemma":[0.9983016,0.0003400432,0.0009719174,0.0001655384,0.0001804651,0.00004040782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004035876,0.0001745097,0.002785384,0.00001909589,0.0001017233,0.000004626001,0.00003581349,1.088396e-7,0.9920821,0.00001171466,0.001894835,0.00248655],"study_design_scores_gemma":[0.001260083,0.0002039584,0.004808447,0.0001074875,0.00001677876,0.00007430088,0.00004481283,2.483583e-7,0.9892871,0.000110862,0.003951135,0.0001348208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976091,0.0009245747,0.0005820602,0.0002300396,0.0002395259,0.00005556283,0.0001521455,0.0000195272,0.0001874228],"genre_scores_gemma":[0.9988227,0.0001070182,0.00002684317,0.00002278845,0.0001374721,0.000002916446,0.00005853231,0.000008929668,0.0008127738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003567331,"threshold_uncertainty_score":0.9973164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354369665818994,"score_gpt":0.2156181485252168,"score_spread":0.2020744518670269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}