{"id":"W2281688700","doi":"10.1039/c6mb00038j","title":"Selectivity profile of afatinib for EGFR-mutated non-small-cell lung cancer","year":2016,"lang":"en","type":"article","venue":"Molecular BioSystems","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Government of Northwest Territories","funders":"","keywords":"Afatinib; Lung cancer; Cancer research; Epidermal growth factor receptor; Biology; Oncology; Internal medicine; Computational biology; Genetics; Medicine; Erlotinib; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001001818,0.0001465929,0.000299945,0.00007555095,0.00004605322,0.000007690644,0.0000590924,0.00008121578,0.00005427725],"category_scores_gemma":[0.00002857924,0.00009396149,0.000127578,0.0001805109,0.00002509525,0.00003060543,0.00001494385,0.00003485515,0.000007116424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002007518,"about_ca_system_score_gemma":0.0003302375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003402329,"about_ca_topic_score_gemma":0.00003996851,"domain_scores_codex":[0.9990681,0.00003178646,0.0002451307,0.0002706965,0.0001529363,0.0002313433],"domain_scores_gemma":[0.9992023,0.00004349308,0.0001482086,0.0002510822,0.0002618339,0.00009311748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009797598,0.0001881927,0.01269096,0.000808536,0.0003706313,0.00001345825,0.0002196444,0.000003997873,0.9823121,0.00006550228,0.001566486,0.001662499],"study_design_scores_gemma":[0.004901218,0.0003611993,0.002362961,0.000617222,0.0005231178,0.000009233043,0.00005189906,0.0006181307,0.9889934,0.000009792921,0.001401546,0.0001502804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764075,0.0009281666,0.01658499,0.0005576789,0.0002586759,0.002558327,0.0002823508,0.0000518927,0.002370388],"genre_scores_gemma":[0.9958188,0.00001678824,0.0009650606,0.00006724716,0.0000715219,0.0007291581,0.00004066622,0.00003776872,0.002253005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01941125,"threshold_uncertainty_score":0.3831638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009134115434847162,"score_gpt":0.3061042228821544,"score_spread":0.2969701074473073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}