{"id":"W2281688700","doi":"10.1039/c6mb00038j","title":"Selectivity profile of afatinib for EGFR-mutated non-small-cell lung cancer","year":2016,"lang":"en","type":"article","venue":"Molecular BioSystems","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Government of Northwest Territories","funders":"","keywords":"Afatinib; Lung cancer; Cancer research; Epidermal growth factor receptor; Biology; Oncology; Internal medicine; Computational biology; Genetics; Medicine; Erlotinib; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001676444,0.000142857,0.0004061117,0.0001686302,0.0001401402,0.0002229807,0.0001933497,0.0001975623,0.0005618494],"category_scores_gemma":[0.0006832627,0.00007496723,0.0002621838,0.000200648,0.00007906977,0.0002146678,0.0001150904,0.0001777416,0.0001919471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000285417,"about_ca_system_score_gemma":0.0003637218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002172749,"about_ca_topic_score_gemma":0.001906718,"domain_scores_codex":[0.9998752,0.00001839668,0.0000078187,0.00003039807,0.00004612891,0.00002202544],"domain_scores_gemma":[0.9998732,0.00006208453,0.00001663489,0.000008596273,0.00002746566,0.00001208508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002507232,0.0002968122,0.03890406,0.0004017554,0.0001581862,0.0005342254,0.0001163287,0.2374683,0.6555738,0.001159373,0.001034378,0.06184557],"study_design_scores_gemma":[0.0001556775,0.003421714,0.02722234,0.00001178823,0.0001544395,0.001158375,0.0001089597,0.448114,0.5146799,0.0006879808,0.004228585,0.00005621412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944856,0.001098568,0.002657421,0.00008238333,0.0000062173,0.00001406094,0.0002604753,0.00004831915,0.001346989],"genre_scores_gemma":[0.9988476,0.0002547003,0.0005260959,0.0000110785,0.000001779478,0.000004500705,0.0001616426,0.000005094231,0.0001874429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002172749,"threshold_uncertainty_score":0.004320264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009134115434847162,"score_gpt":0.3061042228821544,"score_spread":0.2969701074473073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}