{"id":"W2281699589","doi":"10.1158/1538-7445.transcagen-a2-07","title":"Abstract A2-07: Integrative functional genomics of breast cancer","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gene expression and cancer classification","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Synthetic lethality; Druggability; Breast cancer; Cancer; Small hairpin RNA; Biology; Epigenetics; Cancer research; Somatic cell; Computational biology; Gene; Genomics; Functional genomics; Copy-number variation; Drug discovery; Genetics; Bioinformatics; Genome; Gene knockdown; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001597662,0.001027293,0.0008615575,0.0007272945,0.0002777178,0.0007046413,0.0008389393,0.0004261004,0.00352544],"category_scores_gemma":[0.0006360127,0.0003238397,0.001483458,0.0007212851,0.0002519137,0.0002724256,0.0005667958,0.0009064586,0.0008903807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007372848,"about_ca_system_score_gemma":0.0008728274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00290766,"about_ca_topic_score_gemma":0.003729588,"domain_scores_codex":[0.9994593,0.0002152789,0.00001785664,0.0001309796,0.0001270103,0.00004954069],"domain_scores_gemma":[0.9997253,0.0001355138,0.00003440992,0.00003363087,0.00003706784,0.00003399636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00108748,0.0007048142,0.009522331,0.0008674763,0.0007388291,0.0002456047,0.0001681303,0.1289126,0.7066904,0.02783858,0.01298012,0.1102437],"study_design_scores_gemma":[0.0002549529,0.00132507,0.01840621,0.00004839787,0.0003977294,0.0004195942,0.000065991,0.7755379,0.139767,0.01114468,0.05250844,0.0001239884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1932642,0.001264443,0.7602914,0.0006494727,0.000210461,0.0004785453,0.02261254,0.009614196,0.01161478],"genre_scores_gemma":[0.3575411,0.001266203,0.5981275,0.0004054676,0.0001000863,0.001082916,0.03232184,0.001774807,0.007380185],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00352544,"threshold_uncertainty_score":0.01179373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1118395931787554,"score_gpt":0.4034219520591087,"score_spread":0.2915823588803533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}