{"id":"W2281768098","doi":"10.1161/circulationaha.114.015023","title":"9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor–Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Transforming growth factor; Transcription factor; Smooth muscle; Risk factor; Coronary artery disease; Transforming growth factor beta; Cardiology; Internal medicine; Disease; Cancer research; Cell biology; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002009603,0.0005380259,0.0002894122,0.0004263707,0.0001883918,0.0002458474,0.0002915412,0.000451552,0.001946188],"category_scores_gemma":[0.000303028,0.0002294439,0.0006544411,0.0003217419,0.0002400281,0.00006256279,0.0002636354,0.0004557408,0.0006116329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001843508,"about_ca_system_score_gemma":0.0001279788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006494911,"about_ca_topic_score_gemma":0.001021193,"domain_scores_codex":[0.9997819,0.00004890078,0.00002914579,0.00006478239,0.00005128992,0.00002399561],"domain_scores_gemma":[0.9997056,0.00007555966,0.0001364051,0.00003622662,0.000009712296,0.00003643256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003035525,0.00003717879,0.002767041,0.00003613424,0.00004355014,0.0006987613,0.0000269402,0.0001832495,0.9937064,0.0001242812,0.00007865497,0.001994158],"study_design_scores_gemma":[0.0003035959,0.000774005,0.1566112,0.00005545791,0.0003881592,0.01251484,0.00009479893,0.006425879,0.8138605,0.0006193628,0.008312121,0.00004006642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944322,0.0003720373,0.003218399,0.00008815053,0.00002978514,0.00004074417,0.001104515,0.00011824,0.0005960946],"genre_scores_gemma":[0.9960193,0.0001760275,0.002411102,0.00005345276,0.000009164995,0.00003025405,0.000753413,0.00004038306,0.0005068599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001946188,"threshold_uncertainty_score":0.006510615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02300566754392099,"score_gpt":0.2471657908779698,"score_spread":0.2241601233340488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}