{"id":"W2281768098","doi":"10.1161/circulationaha.114.015023","title":"9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor–Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Transforming growth factor; Transcription factor; Smooth muscle; Risk factor; Coronary artery disease; Transforming growth factor beta; Cardiology; Internal medicine; Disease; Cancer research; Cell biology; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002197664,0.0001882597,0.0001855807,0.0001153165,0.00008752416,0.00002020381,0.000101166,0.0001837474,0.00002412766],"category_scores_gemma":[0.0000451601,0.0001913751,0.0001091792,0.00009953557,0.00004048684,0.00004253594,0.00001396459,0.0001111952,0.000003803058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006542587,"about_ca_system_score_gemma":0.00007857544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005684548,"about_ca_topic_score_gemma":0.00002787586,"domain_scores_codex":[0.9984615,0.0001800476,0.0004482653,0.0003973131,0.0002951794,0.0002176592],"domain_scores_gemma":[0.999253,0.000011859,0.0001916512,0.0002786069,0.0000994623,0.0001653771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000110346,0.000143873,0.05078514,0.00004936043,0.00001119365,0.000003293389,0.001005122,0.002112074,0.942439,0.000008373668,0.000002200777,0.003329998],"study_design_scores_gemma":[0.0009847156,0.00007823227,0.6985978,0.0000829453,0.00002887099,9.297088e-7,0.0001063716,0.001742525,0.2977813,0.0003826916,0.00001845001,0.0001951881],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777964,0.0001865631,0.02124592,0.00001221061,0.0001830172,0.0003785481,0.0001169029,0.00002547615,0.00005490498],"genre_scores_gemma":[0.9992913,0.00002713825,0.00008316638,0.00001037228,0.0001028498,0.0000204474,0.0004135524,0.00003089726,0.00002029384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6478127,"threshold_uncertainty_score":0.7804052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02300566754392099,"score_gpt":0.2471657908779698,"score_spread":0.2241601233340488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}