{"id":"W2282189730","doi":"10.1182/blood.v122.21.497.497","title":"First Clinical Results Of a Randomized Phase 2 Study Of SGI-110, a Novel Subcutaneous (SQ) Hypomethylating Agent (HMA), In Adult Patients With Acute Myeloid Leukemia (AML)","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Decitabine; Medicine; Hypomethylating agent; Pharmacodynamics; Internal medicine; Phases of clinical research; Clinical endpoint; Cytarabine; Adverse effect; Gastroenterology; Refractory (planetary science); Myeloid leukemia; Pharmacokinetics; Randomized controlled trial; Surgery; Oncology; Chemotherapy; DNA methylation; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001915581,0.0004132223,0.002343084,0.0004946949,0.00006834148,0.00001892936,0.0003954409,0.0002499614,0.00005887117],"category_scores_gemma":[0.005250977,0.0002943686,0.0003100781,0.0009117584,0.0003726114,0.0001501363,0.0002524699,0.0008446589,0.00002478912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002715343,"about_ca_system_score_gemma":0.0006766186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003196264,"about_ca_topic_score_gemma":0.000332732,"domain_scores_codex":[0.9940563,0.0004810602,0.002718457,0.0007658693,0.001322862,0.0006553785],"domain_scores_gemma":[0.9941464,0.002261033,0.001019379,0.0009995158,0.001208129,0.0003655473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7633891,0.08430094,0.1090294,0.0007574947,0.007776238,0.001946971,0.01102967,0.0001481664,0.01015299,0.00002998482,0.0008020055,0.01063706],"study_design_scores_gemma":[0.9510806,0.01308316,0.02788212,0.000544731,0.001383165,0.00009418337,0.001117539,0.002301868,0.002145971,0.00001291371,0.00002354442,0.0003301803],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992367,0.0000543142,0.00005378773,0.0001655522,0.0000721448,0.006454163,0.000159393,0.00004605145,0.0006276129],"genre_scores_gemma":[0.9943178,0.0001055845,0.0047235,0.00007924678,0.00009312279,0.0003059854,0.00008725771,0.00007414495,0.0002133339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1876915,"threshold_uncertainty_score":0.9999508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194911384319561,"score_gpt":0.3130125473374891,"score_spread":0.2910634334942935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}