{"id":"W2282189730","doi":"10.1182/blood.v122.21.497.497","title":"First Clinical Results Of a Randomized Phase 2 Study Of SGI-110, a Novel Subcutaneous (SQ) Hypomethylating Agent (HMA), In Adult Patients With Acute Myeloid Leukemia (AML)","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Decitabine; Medicine; Hypomethylating agent; Pharmacodynamics; Internal medicine; Phases of clinical research; Clinical endpoint; Cytarabine; Adverse effect; Gastroenterology; Refractory (planetary science); Myeloid leukemia; Pharmacokinetics; Randomized controlled trial; Surgery; Oncology; Chemotherapy; DNA methylation; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002479968,0.00180546,0.001979273,0.0002787524,0.0003754522,0.0007517199,0.0005875205,0.001007905,0.00421907],"category_scores_gemma":[0.001527678,0.0007218898,0.00118267,0.0002207164,0.001232168,0.0006852677,0.0004105128,0.002189348,0.0008822969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000672127,"about_ca_system_score_gemma":0.001104408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004177636,"about_ca_topic_score_gemma":0.0009492944,"domain_scores_codex":[0.9991019,0.000532182,0.00005094869,0.0001363271,0.00006863858,0.0001100176],"domain_scores_gemma":[0.9989857,0.000187725,0.0001915658,0.0001167674,0.00006509959,0.0004529868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8901269,0.04387992,0.00473916,0.0003505363,0.0006941884,0.0001868196,0.0001561024,0.0008785852,0.0265338,0.0001754519,0.002272578,0.03000601],"study_design_scores_gemma":[0.6481782,0.3428604,0.005027003,0.000009461199,0.0002704317,0.00009955611,0.00001764109,0.000433047,0.001825654,0.00009331789,0.001167837,0.00001738073],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914972,0.000963748,0.0006012348,0.000390181,0.0001736668,0.003889451,0.001216902,0.00007703633,0.001190535],"genre_scores_gemma":[0.9838971,0.000946997,0.002516981,0.001274836,0.0004604256,0.00485658,0.003179886,0.00003129221,0.002835799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00421907,"threshold_uncertainty_score":0.01411426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194911384319561,"score_gpt":0.3130125473374891,"score_spread":0.2910634334942935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}