{"id":"W2282394066","doi":"10.1021/jacs.5b10288","title":"Reactive Oxygen Species Mediated Activation of a Dormant Singlet Oxygen Photosensitizer: From Autocatalytic Singlet Oxygen Amplification to Chemicontrolled Photodynamic Therapy","year":2016,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Consejo Nacional de Investigaciones Científicas y Técnicas; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Singlet oxygen; Chemistry; Photosensitizer; BODIPY; Photochemistry; Reactive oxygen species; Phosphorescence; Photodynamic therapy; Autocatalysis; Rose bengal; Oxygen; Fluorescence; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006033905,0.0003484581,0.001178812,0.00009793882,0.0001179045,0.00002490244,0.0005477647,0.0001156881,0.00005217623],"category_scores_gemma":[0.001117111,0.0001916257,0.0008208426,0.0007197374,0.0007605873,0.0001642222,0.000164774,0.000474764,0.000006571756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001311227,"about_ca_system_score_gemma":0.0003443325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002178601,"about_ca_topic_score_gemma":0.000002459264,"domain_scores_codex":[0.9970323,0.0001329184,0.0009066035,0.0003693635,0.001085699,0.0004730577],"domain_scores_gemma":[0.9958082,0.001035957,0.001591748,0.0005979697,0.000703613,0.000262539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00409942,0.0003520138,0.000295467,0.00001576373,0.00147319,0.000003151176,0.001831193,0.00000295615,0.9875512,0.000001611637,0.002190029,0.002184033],"study_design_scores_gemma":[0.004493973,0.0004413606,0.027323,0.0003442165,0.0001402564,0.00002992751,0.001106157,0.0001703392,0.9641915,0.0001682182,0.001366755,0.0002243116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876949,0.0001068941,0.0003064774,0.01076165,0.00007989547,0.0008065726,0.0001177445,0.00003755127,0.00008834407],"genre_scores_gemma":[0.9962183,0.0004548368,0.001035486,0.001733963,0.0003241884,0.00002694982,0.00002605059,0.0000527153,0.0001274654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02702753,"threshold_uncertainty_score":0.781427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171764598955625,"score_gpt":0.2765170132466362,"score_spread":0.2593405533510738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}