{"id":"W2282394066","doi":"10.1021/jacs.5b10288","title":"Reactive Oxygen Species Mediated Activation of a Dormant Singlet Oxygen Photosensitizer: From Autocatalytic Singlet Oxygen Amplification to Chemicontrolled Photodynamic Therapy","year":2016,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Consejo Nacional de Investigaciones Científicas y Técnicas; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Singlet oxygen; Chemistry; Photosensitizer; BODIPY; Photochemistry; Reactive oxygen species; Phosphorescence; Photodynamic therapy; Autocatalysis; Rose bengal; Oxygen; Fluorescence; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706012,0.0002848325,0.0002171786,0.0001172232,0.0001019381,0.0002830529,0.0002985465,0.000362324,0.0005937412],"category_scores_gemma":[0.00008473966,0.0001454402,0.0001956799,0.0001069416,0.0002052555,0.0003178395,0.0002070554,0.0004440804,0.0002286348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002831678,"about_ca_system_score_gemma":0.0001518259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001733339,"about_ca_topic_score_gemma":0.0003006384,"domain_scores_codex":[0.9999065,0.00001051835,0.00000543865,0.0000267607,0.00003469582,0.00001601925],"domain_scores_gemma":[0.9999472,0.000008196206,0.00001547748,0.000008865964,0.00001064565,0.000009666262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001747749,0.00001472557,0.00003819376,0.00002826512,0.000002116252,0.00002322838,0.00001121491,0.00006289801,0.9977859,0.0001373993,0.00001833282,0.001860122],"study_design_scores_gemma":[0.000005387115,0.0001527661,0.0001684591,0.000001499301,0.000004431231,0.00008540456,0.000003010633,0.000379197,0.997607,0.00001935589,0.001571335,0.000002133121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654353,0.004334829,0.0274293,0.0002469266,0.00004956632,0.0001422297,0.0001025367,0.0002293666,0.002030016],"genre_scores_gemma":[0.9748999,0.002379303,0.01856621,0.00009656796,0.00001725334,0.00007501709,0.0001714344,0.00003834444,0.003756067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005937412,"threshold_uncertainty_score":0.002054513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171764598955625,"score_gpt":0.2765170132466362,"score_spread":0.2593405533510738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}