{"id":"W2282398530","doi":"10.1182/blood.v122.21.204.204","title":"Covalent Stabilization Of Coagulation Factor Xa Enhances Its Fibrinolytic Function In Vitro and In Vivo: A Novel Cofactor-Based Thrombolytic Agent","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Blood Services; University of British Columbia","funders":"","keywords":"Plasmin; Fibrinolysis; Fibrin; Chemistry; Biochemistry; Cofactor; Proteolysis; Tissue plasminogen activator; Thrombin; Tissue factor; Plasminogen activator; Coagulation; In vivo; Heparin cofactor II; Enzyme; Platelet; Antithrombin; Biology; Heparin; Immunology; Medicine; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405728,0.0003617157,0.0001920066,0.0001129918,0.00011821,0.0001876328,0.0002716696,0.0002163004,0.001221707],"category_scores_gemma":[0.000139283,0.00009928519,0.0002109319,0.0001050671,0.0001449747,0.0001326104,0.0001313751,0.0003425197,0.0002877476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002365782,"about_ca_system_score_gemma":0.0001575567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003896739,"about_ca_topic_score_gemma":0.0003815957,"domain_scores_codex":[0.9999202,0.0000129475,0.000005522881,0.00001922501,0.00001699361,0.00002501481],"domain_scores_gemma":[0.9999449,0.000006871251,0.00001862915,0.000007210438,0.000007006026,0.000015316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001375978,0.00004755642,0.00007702241,0.00003878607,0.000009706714,0.00004261792,0.000008218278,0.0000970027,0.9971854,0.0001594774,0.00005280986,0.002143676],"study_design_scores_gemma":[0.00003529149,0.0005302692,0.0004273622,0.000002376282,0.00001775289,0.00007158836,0.000001960888,0.000472022,0.9966968,0.00001672817,0.001724616,0.000003305663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904537,0.002132053,0.005590673,0.0001102297,0.00005076933,0.00006654056,0.0001188921,0.00009088496,0.001386216],"genre_scores_gemma":[0.9954025,0.0007107157,0.002229811,0.0000423467,0.0000150984,0.00002188123,0.000132222,0.00001305838,0.00143233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221707,"threshold_uncertainty_score":0.004087031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03486043831964587,"score_gpt":0.2617840094243101,"score_spread":0.2269235711046642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}