{"id":"W2282429204","doi":"","title":"Poly n-butylcyanoacrylate (PNBCA) nanocapsules as a carrier for NSAIDs: in vitro release and in vivo skin penetration.","year":2003,"lang":"en","type":"article","venue":"PubMed","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Nanocapsules; Poloxamer; In vivo; Chromatography; Chemistry; Particle size; Dosage form; Penetration (warfare); Permeation; Transdermal; Bioavailability; Pharmacology; Materials science; Nanoparticle; Membrane; Polymer; Nanotechnology; Organic chemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006884048,0.0002364367,0.0002901378,0.0002333292,0.0001184619,0.00002157798,0.0001473707,0.0002641136,0.0001675295],"category_scores_gemma":[0.0002962318,0.0002566576,0.00006030071,0.0002679717,0.0001568633,0.0002420875,0.00002497923,0.0004260418,0.000007551426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001330466,"about_ca_system_score_gemma":0.00007360692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004858386,"about_ca_topic_score_gemma":0.0001498648,"domain_scores_codex":[0.9979077,0.0003764846,0.0004305571,0.0004310503,0.0001298649,0.0007243726],"domain_scores_gemma":[0.9991291,0.0003575008,0.00008899544,0.0001555654,0.00004355645,0.0002252968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01203062,0.002440592,0.04579466,0.0006142678,0.0005734698,0.0005270019,0.004436312,0.0028286,0.1213795,0.009338121,0.002441242,0.7975956],"study_design_scores_gemma":[0.01192649,0.00007832654,0.02170979,0.00001627945,0.0001382767,0.00004617765,0.0004516959,0.001553829,0.7279714,0.004187964,0.2311278,0.0007919961],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856404,0.005300354,0.0004655055,0.0005014776,0.000695125,0.002273057,0.0002199254,0.00004662855,0.004857511],"genre_scores_gemma":[0.9922643,0.0006679889,0.0006139476,0.001863935,0.00006016058,0.002750529,0.0000152808,0.00003371824,0.001730114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7968036,"threshold_uncertainty_score":0.9999886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05251193789769648,"score_gpt":0.3501428847908661,"score_spread":0.2976309468931696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}