{"id":"W2282429204","doi":"","title":"Poly n-butylcyanoacrylate (PNBCA) nanocapsules as a carrier for NSAIDs: in vitro release and in vivo skin penetration.","year":2003,"lang":"en","type":"article","venue":"PubMed","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Nanocapsules; Poloxamer; In vivo; Chromatography; Chemistry; Particle size; Dosage form; Penetration (warfare); Permeation; Transdermal; Bioavailability; Pharmacology; Materials science; Nanoparticle; Membrane; Polymer; Nanotechnology; Organic chemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001987263,0.0003453933,0.0002131325,0.0001755782,0.0001268705,0.0001585535,0.0001537155,0.0003190591,0.0003712839],"category_scores_gemma":[0.0002339702,0.0001279346,0.0001825909,0.0001037596,0.0001992247,0.0002855868,0.0001129024,0.0002790406,0.000242642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003067817,"about_ca_system_score_gemma":0.0003226182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000736815,"about_ca_topic_score_gemma":0.001444542,"domain_scores_codex":[0.9998749,0.00002471571,0.00001003638,0.00003164215,0.00004291472,0.00001570614],"domain_scores_gemma":[0.9998622,0.0000355458,0.00004690457,0.00001498454,0.00002309579,0.00001717991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006932484,0.00002304854,0.0001016851,0.00006676424,0.000003813485,0.00003514499,0.000004637217,0.00005913845,0.9977031,0.00002225731,0.00001397099,0.001897173],"study_design_scores_gemma":[0.00001452171,0.0006675025,0.001619791,0.000007448452,0.00002122358,0.000222189,0.000006631522,0.0005965022,0.9954674,0.00001275196,0.001359952,0.000004083229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977084,0.01487297,0.006765858,0.0001352738,0.00006982822,0.00009887937,0.00009265641,0.00004089438,0.0008396538],"genre_scores_gemma":[0.9859405,0.004277853,0.007763057,0.00003298973,0.00002205291,0.00006780948,0.0001015519,0.00001110661,0.001783137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000736815,"threshold_uncertainty_score":0.002225876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05251193789769648,"score_gpt":0.3501428847908661,"score_spread":0.2976309468931696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}