{"id":"W2282639786","doi":"10.1371/journal.pone.0149509","title":"Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Research in Japanese Patients","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"","keywords":"Riluzole; Medicine; Placebo; Clinical endpoint; Interim analysis; Amyotrophic lateral sclerosis; Internal medicine; Clinical trial; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003613547,0.001936497,0.004249429,0.0005832613,0.0007836154,0.0008458879,0.0009340904,0.0019138,0.003909461],"category_scores_gemma":[0.001473916,0.0009803403,0.001940965,0.0005459415,0.001237512,0.0008768431,0.0003439886,0.001655193,0.000555011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006970782,"about_ca_system_score_gemma":0.002167256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001625585,"about_ca_topic_score_gemma":0.004575134,"domain_scores_codex":[0.9990095,0.0004998158,0.00009492008,0.000170814,0.0001016343,0.0001233675],"domain_scores_gemma":[0.9992046,0.0001305934,0.0002191555,0.00007775833,0.0001145213,0.0002534711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9239308,0.02285283,0.001238954,0.002525167,0.001965882,0.00009570633,0.0002118362,0.0002218829,0.02015013,0.00008146415,0.0008785519,0.02584676],"study_design_scores_gemma":[0.8676237,0.1268249,0.003024288,0.0000474077,0.00079157,0.0000412872,0.00003648676,0.0001382946,0.0007232717,0.00003971937,0.0006937623,0.00001531134],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786011,0.01094869,0.0006747975,0.0005625751,0.0003804592,0.006969626,0.0007726932,0.0001096444,0.0009804174],"genre_scores_gemma":[0.9690745,0.01023907,0.003686416,0.001728331,0.0007642876,0.01069722,0.0009131814,0.0000352421,0.002861651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004249429,"threshold_uncertainty_score":0.0191105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.177768144253667,"score_gpt":0.3529928430557496,"score_spread":0.1752246988020826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}