{"id":"W2282752971","doi":"10.1074/jbc.m115.677815","title":"BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Parkin; PINK1; Chromosomal translocation; Cell biology; Gene; Mitochondrion; Biology; Genetics; Mitophagy; Apoptosis; Medicine; Autophagy; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434164,0.0004664662,0.0001968917,0.0003370704,0.0002338228,0.0003675827,0.0001604695,0.00020785,0.001544686],"category_scores_gemma":[0.0001058128,0.0001444443,0.0002161035,0.0001798724,0.0002046936,0.0002626281,0.0003408011,0.0004297542,0.0005651585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003824787,"about_ca_system_score_gemma":0.0002179956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002873673,"about_ca_topic_score_gemma":0.0005927919,"domain_scores_codex":[0.9998314,0.00003244652,0.00001596181,0.00004347841,0.00004492663,0.00003175856],"domain_scores_gemma":[0.9998578,0.00001295178,0.00005209596,0.00001104516,0.0000167246,0.00004943616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008645737,0.00001623225,0.0003168523,0.00003432238,0.000004964026,0.0001444237,0.00001030607,0.0000499601,0.9982551,0.0001612487,0.00006451127,0.0008556187],"study_design_scores_gemma":[0.00003233604,0.0001917689,0.02278836,0.000008908922,0.00002708,0.001173237,0.00004909922,0.00222224,0.9655014,0.0002216737,0.007768752,0.00001523378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832389,0.004236404,0.007888018,0.0003104146,0.0001319838,0.00003848286,0.0008695835,0.0003396267,0.002946574],"genre_scores_gemma":[0.9925453,0.000967155,0.001995791,0.00009035537,0.0000181784,0.00003097695,0.0008728006,0.00003498398,0.003444482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001544686,"threshold_uncertainty_score":0.005167484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04134404160484526,"score_gpt":0.2809946779554706,"score_spread":0.2396506363506253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}