{"id":"W2282937734","doi":"10.1128/jvi.02446-15","title":"Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Key Research and Development Program of China; National Institutes of Health; National Natural Science Foundation of China","keywords":"Biology; Tumor necrosis factor alpha; Necrosis; Herpes simplex virus; Virology; Programmed cell death; Cell biology; Protein kinase R; Protein kinase A; Virus; Kinase; Apoptosis; Immunology; Biochemistry; Mitogen-activated protein kinase kinase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008600086,0.000214562,0.0005707882,0.0001711825,0.0001846226,0.00002530505,0.0003798994,0.0002580684,0.0004442327],"category_scores_gemma":[0.0003210898,0.0001428971,0.000187071,0.0001602611,0.0008868138,0.0002132876,0.0001522929,0.0005061961,0.00005859961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004625289,"about_ca_system_score_gemma":0.0001208877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009136825,"about_ca_topic_score_gemma":0.0000606935,"domain_scores_codex":[0.9977088,0.0007649321,0.0008136393,0.0001777418,0.00008555486,0.000449359],"domain_scores_gemma":[0.9983436,0.0003507162,0.0006514085,0.0003072314,0.0002937877,0.00005322618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006630305,0.0009575761,0.0009925695,0.00001827645,0.0008410848,0.00005482816,0.006650832,0.00004240171,0.9172164,0.006228496,0.05005587,0.01031139],"study_design_scores_gemma":[0.004162454,0.002154849,0.01522413,0.00002602656,0.0001459139,0.0008994642,0.002077423,0.00001604926,0.1299717,0.002374931,0.8427417,0.0002053712],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874079,0.007634364,0.0002680637,0.003012107,0.0009373226,0.0001946931,0.00009434022,0.00001645004,0.0004347876],"genre_scores_gemma":[0.9975132,0.0009545835,0.0002240111,0.0003616421,0.0001205127,0.000005680338,0.00002773717,0.00002187376,0.0007707303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7926858,"threshold_uncertainty_score":0.5827175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04177310468942499,"score_gpt":0.2793470003140184,"score_spread":0.2375738956245934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}