{"id":"W2282937734","doi":"10.1128/jvi.02446-15","title":"Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Key Research and Development Program of China; National Institutes of Health; National Natural Science Foundation of China","keywords":"Biology; Tumor necrosis factor alpha; Necrosis; Herpes simplex virus; Virology; Programmed cell death; Cell biology; Protein kinase R; Protein kinase A; Virus; Kinase; Apoptosis; Immunology; Biochemistry; Mitogen-activated protein kinase kinase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001942759,0.0004476823,0.0001746066,0.0001271371,0.00008788181,0.000325772,0.0001913835,0.0002401505,0.001168859],"category_scores_gemma":[0.0001625646,0.00008466728,0.0002774272,0.00009863819,0.0002197136,0.0002211482,0.0002075367,0.0003503905,0.0004026318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002732145,"about_ca_system_score_gemma":0.0001638078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001751634,"about_ca_topic_score_gemma":0.0001688302,"domain_scores_codex":[0.9998187,0.00004471175,0.00002284269,0.00003837742,0.00003372276,0.00004154538],"domain_scores_gemma":[0.9998862,0.00002298016,0.00004620968,0.00001595516,0.0000119275,0.00001677239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489864,0.00002216562,0.0003103251,0.00007486835,0.000007923402,0.00005142359,0.00001475992,0.00004217651,0.9978104,0.0001273595,0.00003170113,0.001357744],"study_design_scores_gemma":[0.00001308429,0.0003277587,0.003767316,0.000008336338,0.00001955802,0.0007018595,0.00003242466,0.0002808741,0.9922943,0.00005241374,0.002498423,0.000003663463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804766,0.0132478,0.0032045,0.0001036863,0.00008681123,0.00004979476,0.0003288179,0.0001242149,0.002377682],"genre_scores_gemma":[0.9932547,0.002953831,0.001826346,0.00004835466,0.00002208914,0.00002976869,0.0003717034,0.00001254502,0.001480522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168859,"threshold_uncertainty_score":0.003910184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04177310468942499,"score_gpt":0.2793470003140184,"score_spread":0.2375738956245934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}