{"id":"W2283105000","doi":"10.1002/ajmg.a.37552","title":"Clinical Report: Cognitive decline in a patient with Cardiofaciocutaneous syndrome","year":2016,"lang":"en","type":"article","venue":"American Journal of Medical Genetics Part A","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University Health Network","funders":"","keywords":"Cognition; Cognitive decline; KRAS; Genetic testing; Medicine; Neuroimaging; Pediatrics; Dementia; Psychiatry; Internal medicine; Disease; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003220374,0.001941408,0.001193328,0.001621223,0.001747609,0.0009570646,0.001485312,0.004439991,0.001608256],"category_scores_gemma":[0.002487153,0.0004387077,0.000762619,0.001121649,0.001300017,0.001089496,0.001090569,0.003405209,0.0006454957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001336966,"about_ca_system_score_gemma":0.001421675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008477191,"about_ca_topic_score_gemma":0.007581585,"domain_scores_codex":[0.9996426,0.00002333538,0.00003736503,0.0001252618,0.00007136843,0.0001000153],"domain_scores_gemma":[0.9986997,0.0002468591,0.0001405113,0.00005863469,0.0001929766,0.0006613177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00004520178,0.0000675491,0.009425023,0.00001531149,0.00001110776,0.9877274,0.0002022113,0.00008812038,0.0007089574,0.000107438,0.0006157676,0.0009860119],"study_design_scores_gemma":[0.00002243536,0.0001727749,0.01683676,0.00001773355,0.00001943293,0.9811839,0.0001530899,0.0003078025,0.0004067882,0.0002261012,0.0006317174,0.00002149342],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727218,0.00205941,0.001799016,0.005658656,0.0005056238,0.0002626564,0.0007279615,0.0002116847,0.01605331],"genre_scores_gemma":[0.9952978,0.0005879875,0.0007559427,0.001367111,0.000355581,0.00002926226,0.0002104178,0.00002306441,0.001372769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008477191,"threshold_uncertainty_score":0.01685566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009362323514051307,"score_gpt":0.299306501664343,"score_spread":0.2899441781502917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}